| http://purl.uniprot.org/citations/32429250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32429250 | http://www.w3.org/2000/01/rdf-schema#comment | "X-ray diffraction and tension measurement experiments were conducted on rat left ventricular skinned fibers with or without "troponin-T treatment," which exchanges the endogenous troponin T/I/C complex with exogenous troponin-T. These experiments were performed to observe the structural changes in troponin-T within a fiber elicited by contractile crossbridge formation and investigate the abnormality of hypertrophic cardiomyopathy-related troponin-T mutants. The intensity of the troponin reflection at 1/38.5 nm-1 was decreased significantly by ATP addition after treatment with wild-type or mutant troponin-T, indicating that crossbridge formation affected the conformation of troponin-T. In experiments on cardiac fibers treated with the hypertrophic cardiomyopathy-related mutants E244D- and K247R-troponin-T, treatment with K247R-troponin-T did not recruit contracting actomyosin to a greater extent than wild-type-troponin-T, although a similar drop in the intensity of the troponin reflection occurred. Therefore, the conformational change in K247R-troponin-T was suggested to be unable to fully recruit actomyosin interaction, which may be the cause of cardiomyopathy."xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms21103520"xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/author | "Akiyama N."xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/author | "Kimura M."xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/author | "Ohno T."xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/author | "Yamaguchi M."xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/author | "Yagi N."xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/author | "Nakahara N."xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/author | "Takemori S."xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/pages | "E3520"xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/title | "Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers."xsd:string |
| http://purl.uniprot.org/citations/32429250 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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