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http://purl.uniprot.org/citations/32434796http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32434796http://www.w3.org/2000/01/rdf-schema#comment"TRP channels function in many types of sensory receptor cells. Despite extensive analyses, an open question is whether there exists a family of auxiliary subunits, which could influence localization, trafficking, and function of TRP channels. Here, using Drosophila melanogaster, we reveal a previously unknown TRP interacting protein, INAF-C, which is expressed exclusively in the ultraviolet-sensing R7 photoreceptor cells. INAF-C is encoded by an unusual locus comprised of four distinct coding regions, which give rise to four unique single-transmembrane-containing proteins. With the exception of INAF-B, roles for the other INAF proteins were unknown. We found that both INAF-B and INAF-C are required for TRP stability and localization in R7 cells. Conversely, loss of just INAF-B greatly reduced TRP from other types of photoreceptor cells, but not R7. The requirements for TRP and INAF are reciprocal, since loss of TRP decreased the concentrations of both INAF-B and INAF-C. INAF-A, which is not normally expressed in photoreceptor cells, can functionally substitute for INAF-B, indicating that it is a third TRP auxiliary protein. Reminiscent of the structural requirements between Kv channels and KCNE auxiliary subunits, the codependencies of TRP and INAF depended on several transmembrane domains (TMDs) in TRP, and the TMD and the C-terminus of INAF-B. Our studies support a model in which the inaF locus encodes a family of at least three TRP auxiliary subunits."xsd:string
http://purl.uniprot.org/citations/32434796http://purl.org/dc/terms/identifier"doi:10.1534/genetics.120.303268"xsd:string
http://purl.uniprot.org/citations/32434796http://purl.uniprot.org/core/author"Chen Z."xsd:string
http://purl.uniprot.org/citations/32434796http://purl.uniprot.org/core/author"Montell C."xsd:string
http://purl.uniprot.org/citations/32434796http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32434796http://purl.uniprot.org/core/name"Genetics"xsd:string
http://purl.uniprot.org/citations/32434796http://purl.uniprot.org/core/pages"713-728"xsd:string
http://purl.uniprot.org/citations/32434796http://purl.uniprot.org/core/title"A Family of Auxiliary Subunits of the TRP Cation Channel Encoded by the Complex inaF Locus."xsd:string
http://purl.uniprot.org/citations/32434796http://purl.uniprot.org/core/volume"215"xsd:string
http://purl.uniprot.org/citations/32434796http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32434796
http://purl.uniprot.org/citations/32434796http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32434796
http://purl.uniprot.org/uniprot/A8WH76#attribution-390332A8FB6182AC6940AE7D81E7961Bhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/A8WH76#attribution-466CE7EF93144B5AAC84C38EAC0B23AAhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/Q6IIF2#attribution-390332A8FB6182AC6940AE7D81E7961Bhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/Q6IIF2#attribution-438DF741E3B707411ECAC8EA1C1D9231http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/Q6IIF2#attribution-466CE7EF93144B5AAC84C38EAC0B23AAhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/A8JUT0#attribution-438DF741E3B707411ECAC8EA1C1D9231http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/#_A0A0B4KHH9-mappedCitation-32434796http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/#_A0A4D6K2U2-mappedCitation-32434796http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/#_A8JUS1-mappedCitation-32434796http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/#_A8JUT0-mappedCitation-32434796http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/#_A8WH76-mappedCitation-32434796http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/#_P48994-mappedCitation-32434796http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32434796
http://purl.uniprot.org/uniprot/#_D3DMF9-mappedCitation-32434796http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32434796