| http://purl.uniprot.org/citations/32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32434871 | http://www.w3.org/2000/01/rdf-schema#comment | "Mesenchymal stromal cells (MSCs) are multipotent progenitors essential for organogenesis, tissue homeostasis, regeneration and scar formation. Tissue injury upregulates transforming growth factor β (TGF-β) signaling, which modulates myofibroblast fate, extracellular matrix remodeling and fibrosis. However, the molecular determinants of MSC differentiation and survival remain poorly understood. During canonical Wnt signaling, T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors regulate development and stemness, but the mechanisms by which injury-induced cues modulate their expression remain underexplored. Here, we studied the cell type-specific gene expression of TCF/LEF transcription factors and, more specifically, we investigated whether damage-induced TGF-β signaling impairs the expression and function of TCF7L2 (also known as TCF4), using several models of MSCs, including skeletal muscle fibro-adipogenic progenitors. We show that TCF/LEFs are differentially expressed and that TGF-β reduces the expression of TCF7L2 in MSCs but not in myoblasts. We also found that the ubiquitin-proteasome system regulates TCF7L2 proteostasis and participates in TGF-β-mediated TCF7L2 protein downregulation. Finally, we show that TGF-β requires histone deacetylase activity to repress the expression of TCF7L2. Thus, our work reports a novel interplay between TGF-β and canonical Wnt signaling cascades in PDGFRα+ fibroblasts and suggests that this mechanism could be targeted in tissue repair and regeneration."xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.242297"xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/author | "Soliman H."xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/author | "Brandan E."xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/author | "Contreras O."xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/author | "Theret M."xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/author | "Rossi F.M.V."xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/pages | "jcs242297"xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/title | "TGF-beta-driven downregulation of the transcription factor TCF7L2 affects Wnt/beta-catenin signaling in PDGFRalphapisup>+pi/sup> fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://purl.uniprot.org/core/volume | "133"xsd:string |
| http://purl.uniprot.org/citations/32434871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32434871 |
| http://purl.uniprot.org/citations/32434871 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUD9-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A023ZT56-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A023ZTV5-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV49-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV87-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YVF3-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1NN66-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS2-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS4-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1PRS6-mappedCitation-32434871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434871 |