| http://purl.uniprot.org/citations/32434989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32434989 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunotherapies that modulate T cell function have been firmly established as a pillar of cancer therapy, whereas the potential for B cells in the antitumor immune response is less established. B cell-activating factor (BAFF) is a B cell-activating cytokine belonging to the TNF ligand family that has been associated with autoimmunity, but little is known about its effects on cancer immunity. We find that BAFF upregulates multiple B cell costimulatory molecules; augments IL-12a expression, consistent with Be-1 lineage commitment; and enhances B cell antigen-presentation to CD4+ Th cells in vitro. In a syngeneic mouse model of melanoma, BAFF upregulates B cell CD40 and PD-L1 expression; it also modulates T cell function through increased T cell activation and TH1 polarization, enhanced expression of the proinflammatory leukocyte trafficking chemokine CCR6, and promotion of a memory phenotype, leading to enhanced antitumor immunity. Similarly, adjuvant BAFF promotes a memory phenotype of T cells in vaccine-draining lymph nodes and augments the antitumor efficacy of whole cell vaccines. BAFF also has distinct immunoregulatory functions, promoting the expansion of CD4+Foxp3+ Tregs in the spleen and tumor microenvironment (TME). Human melanoma data from The Cancer Genome Atlas (TCGA) demonstrate that BAFF expression is positively associated with overall survival and a TH1/IFN-γ gene signature. These data support a potential role for BAFF signaling as a cancer immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.136417"xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Ganguly S."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Jaffee E.M."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Cruz K."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Zaidi N."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Mohan A."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Leatherman J."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Vithayathil T."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Shah Y."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Ho W.J."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Armstrong T.D."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Dennison L."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Yarchoan M."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/author | "Woolman S."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/pages | "136417"xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/title | "Effects of B cell-activating factor on tumor immunity."xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/32434989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32434989 |
| http://purl.uniprot.org/citations/32434989 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32434989 |
| http://purl.uniprot.org/uniprot/#_Q3U106-mappedCitation-32434989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434989 |
| http://purl.uniprot.org/uniprot/#_Q3SXS6-mappedCitation-32434989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32434989 |