| http://purl.uniprot.org/citations/32436108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32436108 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkinson's disease (PD) is a progressive neurodegenerative disease highlighted by a marked loss of dopaminergic cell loss and motor disturbances. Currently, there are no drugs that slow the progression of the disease. A myriad of factors have been implicated in the pathogenesis and progression of PD including neuroinflammation. Although anti-inflammatory agents are being evaluated as potential disease-modifying therapies for PD, none has proven effective to date, suggesting that new and novel targets are needed. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that has recently been shown to reduce inflammation in astrocytes and to be increased in post-mortem PD brain samples. Here we show that transgenic overexpression of GPNMB protects against dopaminergic neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropridine mouse model of Parkinson's disease. Furthermore, GPNMB overexpression reduces gliosis and prevented microglial morphological changes following MPTP treatment compared with wild-type MPTP-treated mice. Additionally, recombinant GPNMB attenuates LPS-induced inflammation in primary mouse microglia. These results suggest a neuroprotective and anti-inflammatory role for GPNMB and warrant further investigation for GPNMB as a novel therapy for PD."xsd:string |
| http://purl.uniprot.org/citations/32436108 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12035-020-01921-6"xsd:string |
| http://purl.uniprot.org/citations/32436108 | http://purl.uniprot.org/core/author | "Safadi F.F."xsd:string |
| http://purl.uniprot.org/citations/32436108 | http://purl.uniprot.org/core/author | "Richardson J.R."xsd:string |
| http://purl.uniprot.org/citations/32436108 | http://purl.uniprot.org/core/author | "Neal M.L."xsd:string |
| http://purl.uniprot.org/citations/32436108 | http://purl.uniprot.org/core/author | "Budge K.M."xsd:string |
| http://purl.uniprot.org/citations/32436108 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32436108 | http://purl.uniprot.org/core/name | "Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/32436108 | http://purl.uniprot.org/core/pages | "2920-2933"xsd:string |
| http://purl.uniprot.org/citations/32436108 | http://purl.uniprot.org/core/title | "Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/32436108 | http://purl.uniprot.org/core/volume | "57"xsd:string |
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