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http://purl.uniprot.org/citations/32437666http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32437666http://www.w3.org/2000/01/rdf-schema#comment"

Background

The underlying pathomechanism in placenta-related selective fetal growth restriction in monochorionic diamniotic twin pregnancy is not known.

Objective

This study aimed to investigate any differences in placental transcriptomic profile between the selectively growth-restricted twins and the normally grown cotwins in monochorionic diamniotic twin pregnancies.

Study design

This was a prospective study of monochorionic diamniotic twin pregnancies complicated by selective fetal growth restriction. Placental biopsy specimens were obtained from the subjects in the delivery suite. The placental transcriptome of the selectively growth-restricted twin was compared with that of the normally grown cotwin. This study was divided into 2 stages: (1) gene discovery phase in which placental tissues from 5 monochorionic diamniotic twin pregnancies complicated by selective fetal growth restriction plus 2 control twin pregnancies underwent transcriptome profiling, and transcriptome profiling was carried out using whole-genome RNA sequencing; and (2) validation phase in which placental tissues from 13 monochorionic diamniotic twin pregnancies with selective fetal growth restriction underwent RNA and protein validation. RNA and protein expression levels of candidate genes were determined using quantitative real-time polymerase chain reaction and immunohistochemistry staining.

Results

A total of 1429 transcripts were differentially expressed in the placentae of selectively growth-restricted twin pairs, where 610 were up-regulated and 819 were down-regulated. Endoplasmic reticulum lectin and mannose 6-phosphate receptor were consistently differentially up-regulated in all placentae of selectively growth-restricted twins. Quantitative real-time polymerase chain reaction and immunohistochemistry staining were used to validate the results (P<.05).

Conclusion

The expression of endoplasmic reticulum lectin and mannose 6-phosphate receptor, which are important for angiogenesis and fetal growth, was significantly increased in the placentae of selectively growth-restricted twin of a monochorionic twin pair."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.org/dc/terms/identifier"doi:10.1016/j.ajog.2020.05.008"xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Li W."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Wu L."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Wang C.C."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Chan T.F."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Leung T.Y."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Chung C.Y.L."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Chaemsaithong P."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Chan O.K."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Cheng Y.K.Y."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Appiah K."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Leung M.B.W."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/author"Poon L.C.Y."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/name"Am J Obstet Gynecol"xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/pages"749.e1-749.e16"xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/title"Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis."xsd:string
http://purl.uniprot.org/citations/32437666http://purl.uniprot.org/core/volume"223"xsd:string
http://purl.uniprot.org/citations/32437666http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32437666
http://purl.uniprot.org/citations/32437666http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32437666
http://purl.uniprot.org/uniprot/#_B4DH11-mappedCitation-32437666http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32437666
http://purl.uniprot.org/uniprot/#_A4UCT8-mappedCitation-32437666http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32437666
http://purl.uniprot.org/uniprot/#_B2R6S2-mappedCitation-32437666http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32437666
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