| http://purl.uniprot.org/citations/32439656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32439656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32439656 | http://www.w3.org/2000/01/rdf-schema#comment | "A defining step in the biogenesis of a membrane protein is the insertion of its hydrophobic transmembrane helices into the lipid bilayer. The nine-subunit endoplasmic reticulum (ER) membrane protein complex (EMC) is a conserved co- and posttranslational insertase at the ER. We determined the structure of the human EMC in a lipid nanodisc to an overall resolution of 3.4 angstroms by cryo-electron microscopy, permitting building of a nearly complete atomic model. We used structure-guided mutagenesis to demonstrate that substrate insertion requires a methionine-rich cytosolic loop and occurs via an enclosed hydrophilic vestibule within the membrane formed by the subunits EMC3 and EMC6. We propose that the EMC uses local membrane thinning and a positively charged patch to decrease the energetic barrier for insertion into the bilayer."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abb5008"xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abb5008"xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Inglis A.J."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Inglis A.J."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Voorhees R.M."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Voorhees R.M."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Januszyk K."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Januszyk K."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Hazu M."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Hazu M."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Pleiner T."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Pleiner T."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Tomaleri G.P."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/author | "Tomaleri G.P."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/pages | "433-436"xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/pages | "433-436"xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/title | "Structural basis for membrane insertion by the human ER membrane protein complex."xsd:string |
| http://purl.uniprot.org/citations/32439656 | http://purl.uniprot.org/core/title | "Structural basis for membrane insertion by the human ER membrane protein complex."xsd:string |