| http://purl.uniprot.org/citations/32453474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32453474 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and aim11β-Hydroxysteroid dehydrogenase 1 has been implicated in insulin resistance (IR) in the setting of metabolic disorders, and single nucleotide polymorphisms (SNPs) in its encoding gene (HSD11B1) have been associated with type 2 diabetes and metabolic syndrome. In type 1 diabetes (T1D), IR has been related to the development of chronic complications. We investigated the association of HSD11B1 SNPs with microvascular complications and with IR in a Brazilian cohort of T1D individuals.Materials and methodsFive SNPs were genotyped in 466 T1D individuals (57% women; median of 37 years old, diabetes duration of 25 years and HbA1c of 8.4%).ResultsThe minor allele T of rs11799643 was nominally associated with diabetic retinopathy (OR = 0.52; confidence interval [CI] 95% = 0.28-0.96; P = .036). The minor allele C of rs17389016 was nominally associated with overt diabetic kidney disease (DKD) (OR = 1.90; CI 95% = 1.07-3.37; P = .028). A follow-up study revealed that 29% of the individuals lost ≥5 mL min-1 × 1.73 m2 per year of the estimated glomerular filtration rate (eGFR). In these individuals (eGFR decliners), C allele of rs17389016 was more frequent than in non-decliners (OR = 2.10; CI 95% = 1.14-3.89; P = .018). Finally, minor allele T of rs846906 associated with higher prevalence of arterial hypertension, higher body mass index and waist circumference, thus conferring risk to a lower estimated glucose disposal rate, a surrogate marker of insulin sensitivity (OR = 1.23; CI 95% = 1.06-1.42; P = .004).ConclusionSNPs in the HSD11B1 gene may confer susceptibility to DKD and to IR in T1D individuals."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.org/dc/terms/identifier | "doi:10.1002/dmrr.3352"xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Machado U.F."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Machado C.G."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Correa-Giannella M.L."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Mori R.C."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Monteiro M.B."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Queiroz M.S."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Admoni S.N."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Perez R.V."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Santos-Bezerra D.P."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/author | "Pelaes T.S."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/name | "Diabetes Metab Res Rev"xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/pages | "e3352"xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/title | "Variants in HSD11B1 gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/32453474 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32453474 |
| http://purl.uniprot.org/citations/32453474 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32453474 |
| http://purl.uniprot.org/uniprot/#_P28845-mappedCitation-32453474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32453474 |
| http://purl.uniprot.org/uniprot/#_X5D2L1-mappedCitation-32453474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32453474 |
| http://purl.uniprot.org/uniprot/P28845 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32453474 |
| http://purl.uniprot.org/uniprot/X5D2L1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32453474 |