| http://purl.uniprot.org/citations/32471869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32471869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32471869 | http://www.w3.org/2000/01/rdf-schema#comment | "The RIG-I-like receptors (RLRs) retinoic acid-inducible gene I protein (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are cytosolic pattern recognition receptors that recognize specific viral RNA products and initiate antiviral innate immunity. Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly pathogenic member of the Bunyavirales RIG-I, but not MDA5, has been suggested to sense some bunyavirus infections; however, the roles of RLRs in anti-SFTSV immune responses remain unclear. Here, we show that SFTSV infection induces an antiviral response accompanied by significant induction of antiviral and inflammatory cytokines and that RIG-I plays a main role in this induction by recognizing viral 5'-triphosphorylated RNAs and by signaling via the adaptor mitochondrial antiviral signaling protein. Moreover, MDA5 may also sense SFTSV infection and contribute to IFN induction, but to a lesser extent. We further demonstrate that the RLR-mediated anti-SFTSV signaling can be antagonized by SFTSV nonstructural protein (NSs) at the level of RIG-I activation. Protein interaction and MS-based analyses revealed that NSs interacts with the host protein tripartite motif-containing 25 (TRIM25), a critical RIG-I-activating ubiquitin E3 ligase, but not with RIG-I or Riplet, another E3 ligase required for RIG-I ubiquitination. NSs specifically trapped TRIM25 into viral inclusion bodies and inhibited TRIM25-mediated RIG-I-Lys-63-linked ubiquitination/activation, contributing to suppression of RLR-mediated antiviral signaling at its initial stage. These results provide insights into immune responses to SFTSV infection and clarify a mechanism of the viral immune evasion, which may help inform the development of antiviral therapeutics."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra120.013973"xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra120.013973"xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/author | "Deng F."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/author | "Deng F."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/author | "Min Y.Q."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/author | "Min Y.Q."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/author | "Ning Y.J."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/author | "Ning Y.J."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/pages | "9691-9711"xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/pages | "9691-9711"xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/title | "A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/title | "A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/volume | "295"xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://purl.uniprot.org/core/volume | "295"xsd:string |
| http://purl.uniprot.org/citations/32471869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32471869 |
| http://purl.uniprot.org/citations/32471869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32471869 |