| http://purl.uniprot.org/citations/32474254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32474254 | http://www.w3.org/2000/01/rdf-schema#comment | "Myeloid-derived suppressor cells (MDSCs) contribute to high mortality rates during sepsis, but how sepsis induces MDSCs is unclear. Previously we reported that microRNA (miR)-21 and miR-181b reprogram MDSCs in septic mice by increasing levels of DNA binding transcription factor, nuclear factor 1 (NFI-A). Here, we provide evidence that miR-21 and miR-181b stabilize NFI-A mRNA and increase NFI-A protein levels by recruiting RNA-binding proteins HuR and Ago1 to its 3' untranslated region (3'UTR). We also find that the NFI-A GU-rich element (GRE)-binding protein CUGBP1 counters miR-21 and miR-181b dependent NFI-A mRNA stabilization and decreases protein production by replacing 3'UTR bound Ago1 with Ago2. We confirmed the miR-21 and miR-181b dependent reprogramming pathway in MDSCs transfected with a luciferase reporter construct containing an NFI-A 3'UTR fragment with point mutations in the miRNA binding sites. These results suggest that targeting NFI-A in MDSCs during sepsis may enhance resistance to uncontrolled infection."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2020.04.014"xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/author | "Yao Z.Q."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/author | "El Gazzar M."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/author | "McCall C.E."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/author | "Youssef D."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/author | "Bah I."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/author | "Kumbhare A."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/author | "Alkhateeb T."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/author | "Hawkin G.A."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/pages | "97-105"xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/title | "HuR promotes miRNA-mediated upregulation of NFI-A protein expression in MDSCs during murine sepsis."xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/32474254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32474254 |
| http://purl.uniprot.org/citations/32474254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32474254 |
| http://purl.uniprot.org/uniprot/#_B1AUC0-mappedCitation-32474254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32474254 |
| http://purl.uniprot.org/uniprot/#_P70372-mappedCitation-32474254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32474254 |
| http://purl.uniprot.org/uniprot/#_Q05B39-mappedCitation-32474254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32474254 |
| http://purl.uniprot.org/uniprot/#_Q8BTQ1-mappedCitation-32474254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32474254 |
| http://purl.uniprot.org/uniprot/#_Q02780-mappedCitation-32474254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32474254 |
| http://purl.uniprot.org/uniprot/#_Q3TT05-mappedCitation-32474254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32474254 |
| http://purl.uniprot.org/uniprot/#_Q3UTK6-mappedCitation-32474254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32474254 |