| http://purl.uniprot.org/citations/32479258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32479258 | http://www.w3.org/2000/01/rdf-schema#comment | "The body plan along the anteroposterior axis and regional identities are specified by the spatiotemporal expression of Hox genes. Multistep controls are required for their unique expression patterns; however, the molecular mechanisms behind the tight control of Hox genes are not fully understood. In this study, we demonstrated that the Lin28a/let-7 pathway is critical for axial elongation. Lin28a-/- mice exhibited axial shortening with mild skeletal transformations of vertebrae, which were consistent with results in mice with tail bud-specific mutants of Lin28a. The accumulation of let-7 in Lin28a-/- mice resulted in the reduction of PRC1 occupancy at the Hox cluster loci by targeting Cbx2. Consistently, Lin28a loss in embryonic stem-like cells led to aberrant induction of posterior Hox genes, which was rescued by the knockdown of let-7. These results suggest that the Lin28/let-7 pathway is involved in the modulation of the 'Hox code' via Polycomb regulation during axial patterning."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.53608"xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Ito Y."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Kataoka K."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Mori M."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Takahashi S."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Inui M."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Asahara H."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Akita K."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/author | "Ueno-Kudoh H."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/pages | "e53608"xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/title | "Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates."xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32479258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32479258 |
| http://purl.uniprot.org/citations/32479258 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32479258 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J193-mappedCitation-32479258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32479258 |
| http://purl.uniprot.org/uniprot/#_A0A087WR88-mappedCitation-32479258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32479258 |
| http://purl.uniprot.org/uniprot/#_D3Z207-mappedCitation-32479258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32479258 |
| http://purl.uniprot.org/uniprot/#_D3Z208-mappedCitation-32479258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32479258 |