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Purpose

The purpose of the study is to evaluate the expression of NRP-2 and explore its role in Laryngeal squamous cell carcinoma (LSCC).

Materials and methods

NRP-2 expression in 70 primary LSCC tissue specimens were analyzed by immunohistochemistry and correlated with clinicopathological parameters and patients´ survival rate. Additionally, 9 paired LSCC tissues were evaluated for NRP-2 expression by Western blotting.

Results

The Western blotting indicated that NRP-2 expression levels in LSCC were significantly higher than those in the paraneoplastic tissues (P < 0.05). Immunohistochemistry staining revealed that NRP-2 was detected in all primary tumor samples, moreover, high expression of NRP-2 was significantly correlated with TNM stage (P < 0.05), clinical stage (P < 0.05), histological classification (P < 0.05), lymph node metastasis (P < 0.05) and recurrence (P = 0.001). Survival curves determined by the Kaplan-Meier method showed that high expression of NRP-2 can reduce overall survival (both group P < 0.05). Then we combined the NRP-2 expression and lymph node status, and Kaplan-Meier survival showed patients with high expression of NRP-2 or lymph node metastasis (+) had both shorter disease-free and overall survival than others (both P < 0.05). Multivariate Cox proportional hazards model analysis confirmed that histological grade (P = 0.045), lymph node metastasis (P = 0.020) and high expression of NRP-2 (P = 0.033) were statistically significant, independent predictor of prognosis.

Conclusions

NRP-2 may contribute to LSCC progression and represents as a novel prognostic indicator as well as a potential therapeutic target for LSCC."xsd:string
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http://purl.uniprot.org/citations/32480134http://purl.uniprot.org/core/author"Huang P."xsd:string
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http://purl.uniprot.org/citations/32480134http://purl.uniprot.org/core/author"Yin D."xsd:string
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http://purl.uniprot.org/citations/32480134http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32480134http://purl.uniprot.org/core/name"Am J Otolaryngol"xsd:string
http://purl.uniprot.org/citations/32480134http://purl.uniprot.org/core/pages"102540"xsd:string
http://purl.uniprot.org/citations/32480134http://purl.uniprot.org/core/title"Clinical significance of neuropilin-2 expression in laryngeal squamous cell carcinoma."xsd:string
http://purl.uniprot.org/citations/32480134http://purl.uniprot.org/core/volume"41"xsd:string
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