| http://purl.uniprot.org/citations/32483339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32483339 | http://www.w3.org/2000/01/rdf-schema#comment | "Human insulin and its current therapeutic analogs all show propensity, albeit varyingly, to self-associate into dimers and hexamers, which delays their onset of action and makes blood glucose management difficult for people with diabetes. Recently, we described a monomeric, insulin-like peptide in cone-snail venom with moderate human insulin-like bioactivity. Here, with insights from structural biology studies, we report the development of mini-Ins-a human des-octapeptide insulin analog-as a structurally minimal, full-potency insulin. Mini-Ins is monomeric and, despite the lack of the canonical B-chain C-terminal octapeptide, has similar receptor binding affinity to human insulin. Four mutations compensate for the lack of contacts normally made by the octapeptide. Mini-Ins also has similar in vitro insulin signaling and in vivo bioactivities to human insulin. The full bioactivity of mini-Ins demonstrates the dispensability of the PheB24-PheB25-TyrB26 aromatic triplet and opens a new direction for therapeutic insulin development."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-020-0430-8"xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Xiong X."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Lawrence M.C."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Norton R.S."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Smith B.J."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Smith N.A."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "MacRaild C.A."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Agrawal R."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Gajewiak J."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Safavi-Hemami H."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Fisher S.J."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Olivera B."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Forbes B.E."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Chou D.H."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Disotuar M.M."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Menting J.G."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Ghabash G."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/author | "Delaine C.A."xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/32483339 | http://purl.uniprot.org/core/pages | "615-624"xsd:string |