| http://purl.uniprot.org/citations/32493841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32493841 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients with systemic lupus erythematosus (SLE) present a high incidence of atherosclerosis, which contributes significantly to morbidity and mortality in this autoimmune disease. An impaired balance between regulatory (Treg) and follicular helper (Tfh) CD4+ T cells is shared by both diseases. However, whether there are common mechanisms of CD4+ T cell dysregulation between SLE and atherosclerosis remains unclear. Pre-B cell leukemia transcription factor 1 isoform d (Pbx1d) is a lupus susceptibility gene that regulates Tfh cell expansion and Treg cell homeostasis. Here, we investigated the role of T cells overexpressing Pbx1d in low-density lipoprotein receptor-deficient (Ldlr-/-) mice fed with a high-fat diet, an experimental model for atherosclerosis. Pbx1d-transgenic T cells exacerbated some phenotypes of atherosclerosis, which were associated with higher autoantibody production, increased Tfh cell frequency, and impaired Treg cell regulation, in Ldlr-/-mice as compared with control T cells. In addition, we showed that dyslipidemia and Pbx1d-transgenic expression independently impaired the differentiation and function of Treg cells in vitro, suggesting a gene/environment additive effect. Thus, our results suggest that the combination of Pbx1d expression in T cells and dyslipidemia exacerbates both atherosclerosis and autoimmunity, at least in part through a dysregulation of Treg cell homeostasis."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.138274"xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Brown J."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Zou X."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Teng X."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Choi S.C."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Morel L."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Major A."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Abboud G."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Elshikha A.S."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Cornaby C."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Fredenburg K."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Robusto B."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/author | "Zeumer-Spataro L."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/pages | "138274"xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/title | "T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice."xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/32493841 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32493841 |
| http://purl.uniprot.org/citations/32493841 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32493841 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SRE8-mappedCitation-32493841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32493841 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-32493841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32493841 |