| http://purl.uniprot.org/citations/32500475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32500475 | http://www.w3.org/2000/01/rdf-schema#comment | "The modulatory roles of numerous circular RNAs (circRNAs) have been exposited in atherosclerosis (AS). Our study paid attention to the function of circRNA_ 0124644 (circ_0124644) in AS development, as well as its functional mechanism. The AS cell model was established by the treatment of oxidized low-density lipoprotein (ox-LDL) to human vascular endothelial cells (HUVECs). Cell proliferation and cycle were severally measured by Cell Counting Kit-8 (CCK-8) and cell cycle detection kit. The examination of apoptosis rate was executed through flow cytometry. Western blot was exploited for detecting the associated proteins. The expression levels of circ_0124644 and microRNA-149-5p (miR-149-5p) and pregnancy-associated plasma protein-A (PAPP-A) were assayed using quantitative real-time polymerase chain reaction. The combination of targets was validated via the dual-luciferase reporter assay, RNA immunoprecipitation (RIP), and RNA pull-down assay. Clonal capacity was analyzed using colony formation assay. Ox-LDL restrained HUVECs proliferation and cycle, but facilitated apoptosis. Circ_0124644 expression was increased, while miR-149-5p was downregulated in ox-LDL-treated HUVECs. Besides, circ_0124644 served as a molecular sponge of miR-149-5p and intensified the ox-LDL-induced HUVECs injury by sponging miR-149-5p. PAPP-A was a target of miR-149-5p and miR-149-5p could mitigate the HUVECs injury caused by ox-LDL through inhibiting PAPP-A. Moreover, PAPP-A was positively regulated by circ_0124644 via the miR-149-5p. In this report, we concluded the promoted role of circ_0124644 in the ox-LDL-induced endothelial injury of HUVECs via the miR-149-5p/PAPP-A axis with an emphasis on its diagnostic and therapeutic values in AS."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-020-03764-0"xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Fan Z."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Niu L."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Li Y.'"xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/author | "Lei Z."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/pages | "51-61"xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/title | "Circular RNA circ_0124644 exacerbates the ox-LDL-induced endothelial injury in human vascular endothelial cells through regulating PAPP-A by acting as a sponge of miR-149-5p."xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://purl.uniprot.org/core/volume | "471"xsd:string |
| http://purl.uniprot.org/citations/32500475 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32500475 |
| http://purl.uniprot.org/citations/32500475 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32500475 |
| http://purl.uniprot.org/uniprot/#_B4DTA7-mappedCitation-32500475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32500475 |
| http://purl.uniprot.org/uniprot/#_B4DTA8-mappedCitation-32500475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32500475 |
| http://purl.uniprot.org/uniprot/#_Q13219-mappedCitation-32500475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32500475 |
| http://purl.uniprot.org/uniprot/#_Q5QFB7-mappedCitation-32500475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32500475 |