| http://purl.uniprot.org/citations/32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32501282 | http://www.w3.org/2000/01/rdf-schema#comment | "Primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by small brain size with mental retardation. CPAP (also known as CENPJ), a known microcephaly-associated gene, plays a key role in centriole biogenesis. Here, we generated a previously unreported conditional knockout allele in the mouse Cpap gene. Our results showed that conditional Cpap deletion in the central nervous system preferentially induces formation of monopolar spindles in radial glia progenitors (RGPs) at around embryonic day 14.5 and causes robust apoptosis that severely disrupts embryonic brains. Interestingly, microcephalic brains with reduced apoptosis are detected in conditional Cpap gene-deleted mice that lose only one allele of p53 (also known as Trp53), while simultaneous removal of p53 and Cpap rescues RGP death. Furthermore, Cpap deletion leads to cilia loss, RGP mislocalization, junctional integrity disruption, massive heterotopia and severe cerebellar hypoplasia. Together, these findings indicate that complete CPAP loss leads to severe and complex phenotypes in developing mouse brain, and provide new insights into the causes of MCPH."xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.243592"xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://purl.uniprot.org/core/author | "Tang T.K."xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://purl.uniprot.org/core/author | "Lin Y.N."xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://purl.uniprot.org/core/author | "Li S.K."xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32501282 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://purl.uniprot.org/core/pages | "jcs243592"xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://purl.uniprot.org/core/title | "Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly."xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://purl.uniprot.org/core/volume | "133"xsd:string |
| http://purl.uniprot.org/citations/32501282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32501282 |
| http://purl.uniprot.org/citations/32501282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32501282 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E1-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_D3YYT0-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_E0CXR8-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_E0CY24-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_E0CYB6-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_E0CZ83-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_E0CZE2-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_P63015-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-32501282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32501282 |