| http://purl.uniprot.org/citations/32509789 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32509789 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematopoiesis is a necessary process for development and immune defense in Drosophila from the embryonic period to adulthood. There are two main stages in this process: the first stage occurs in the head mesoderm during the embryonic stage, and the second occurs in a specialized hematopoietic organ along the dorsal vessel, the lymph gland, during the larval stage. The lymph gland consists of paired lobes, each of which has distinct regions: the cortical zone (CZ), which contains mature hemocytes; the medullary zone (MZ), which contains hematopoietic progenitors; and the posterior signaling center (PSC), which specifically expresses the early B-cell factor (EBF) transcription factor Collier (Col) and the HOX factor Antennapedia (Antp) to form a microenvironment similar to that of the mammalian bone marrow hematopoietic stem cell niche. The PSC plays a key role in regulating hematopoietic progenitor differentiation. Moreover, the PSC contributes to the cellular immune response to wasp parasitism triggered by elevated ROS levels. Two recent studies have revealed that hematopoietic progenitor maintenance is directly regulated by Col expressed in the MZ and is independent of the PSC, challenging the traditional model. In this review, we summarize the regulatory networks of PSC cell proliferation, the controversy regarding PSC-mediated regulation of hematopoietic progenitor differentiation, and the wasp egg infection response. In addition, we discuss why the PSC is an ideal model for investigating mammalian hematopoietic stem cell niches and leukemia."xsd:string |
| http://purl.uniprot.org/citations/32509789 | http://purl.org/dc/terms/identifier | "doi:10.3389/fcell.2020.00382"xsd:string |
| http://purl.uniprot.org/citations/32509789 | http://purl.uniprot.org/core/author | "Yu S."xsd:string |
| http://purl.uniprot.org/citations/32509789 | http://purl.uniprot.org/core/author | "Luo F."xsd:string |
| http://purl.uniprot.org/citations/32509789 | http://purl.uniprot.org/core/author | "Jin L.H."xsd:string |
| http://purl.uniprot.org/citations/32509789 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32509789 | http://purl.uniprot.org/core/name | "Front Cell Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/32509789 | http://purl.uniprot.org/core/pages | "382"xsd:string |
| http://purl.uniprot.org/citations/32509789 | http://purl.uniprot.org/core/title | "The Posterior Signaling Center Is an Important Microenvironment for Homeostasis of the Drosophila Lymph Gland."xsd:string |
| http://purl.uniprot.org/citations/32509789 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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