| http://purl.uniprot.org/citations/32521253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32521253 | http://www.w3.org/2000/01/rdf-schema#comment | "B cells produce high amounts of cytokines and immunoglobulins in response to lipopolysaccharide (LPS) stimulation. Calcium signaling cascades are critically involved in cytokine production of T cells, and the cytosolic calcium concentration is regulated by calcium-activated monovalent cation channels (CAMs). Calcium signaling is also implicated in B cell activation; however, its involvement in the cytokine production of LPS-stimulated B cells remains less well characterized. Here, we show that the transient receptor potential melastatin 5 channel (TRPM5), which is one of the CAMs, negatively modulates calcium signaling, thereby regulating LPS-induced proliferative and inflammatory responses by B cells. LPS-stimulated B cells of Trpm5-deficient mice exhibit an increased cytosolic calcium concentration, leading to enhanced proliferation and the production of the inflammatory cytokines interleukin-6 and CXCL10. Furthermore, Trpm5-deficient mice show an exacerbation of endotoxic shock with high mortality. Our findings demonstrate the importance of TRPM5-dependent regulatory mechanisms in LPS-induced calcium signaling of splenic B cells."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.107755"xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Baba Y."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Okamura Y."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Miyake K."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Sakaguchi T."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Ohtani T."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Okuzaki D."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Ono C."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Sakata Y."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Kioka H."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Umemoto E."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Tanimura N."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Kayama H."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Okumura R."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/author | "Okochi Y."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/pages | "107755"xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/title | "TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/32521253 | http://purl.uniprot.org/core/volume | "31"xsd:string |