| http://purl.uniprot.org/citations/32521261 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32521261 | http://www.w3.org/2000/01/rdf-schema#comment | "Dietary nutrients shape complex interactions between hosts and their commensal gut bacteria, further promoting flexibility in host-microbiota associations that can drive nutritional symbiosis. However, it remains less clear if diet-dependent host signaling mechanisms also influence these associations. Using Drosophila, we show here that nuclear factor κB (NF-κB)/Relish, an innate immune transcription factor emerging as a signaling node linking nutrient-immune-metabolic interactions, is vital to adapt gut microbiota species composition to host diet macronutrient composition. We find that Relish is required within midgut enterocytes to amplify host-Lactobacillus associations, an important bacterial mediator of nutritional symbiosis, and thus modulate microbiota composition in response to dietary adaptation. Relish limits diet-dependent transcriptional inducibility of the cap-dependent translation inhibitor 4E-BP/Thor to control microbiota composition. Furthermore, maintaining cap-dependent translation in response to dietary adaptation is critical to amplify host-Lactobacillus associations. These results highlight that NF-κB-dependent host signaling mechanisms, in coordination with host translation control, shape diet-microbiota interactions."xsd:string |
| http://purl.uniprot.org/citations/32521261 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.107736"xsd:string |
| http://purl.uniprot.org/citations/32521261 | http://purl.uniprot.org/core/author | "Karpac J."xsd:string |
| http://purl.uniprot.org/citations/32521261 | http://purl.uniprot.org/core/author | "Molaei M."xsd:string |
| http://purl.uniprot.org/citations/32521261 | http://purl.uniprot.org/core/author | "Vandehoef C."xsd:string |
| http://purl.uniprot.org/citations/32521261 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32521261 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32521261 | http://purl.uniprot.org/core/pages | "107736"xsd:string |
| http://purl.uniprot.org/citations/32521261 | http://purl.uniprot.org/core/title | "Dietary Adaptation of Microbiota in Drosophila Requires NF-kappaB-Dependent Control of the Translational Regulator 4E-BP."xsd:string |
| http://purl.uniprot.org/citations/32521261 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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