Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/32522384http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32522384http://www.w3.org/2000/01/rdf-schema#comment"

Background

HLA-Cw*0602 has long been established as one of the most important genetic biomarkers in psoriasis. However, the epigenetic and gene expression differences between HLA-Cw*0602 carriers and non-carriers has not yet been investigated.

Objective

We aim to explore the whole-genome methylation and gene expression differences between HLA-Cw*0602 carriers and non-carriers.

Methods

HLA imputation was performed to get landscape of variants in this region. Genome-wide DNA methylation was compared between positive and negative HLA-Cw*0602 groups. Eleven methylation loci were selected for further validation in additional 43 cases. For differentially methylated genes, GO and KEGG were used to annotate gene functions.

Results

We imputed 29,948 variants based on the constructed HLA reference panels, and obtained 42 HLA-Cw*0602 carriers and 72 non-carriers. Significant methylation differences were detected at 4321 sites (811 hypo- and 3510 hypermethylated). The cg02607779 (KLF7, P = 0.001), cg06936779 (PIP5K1A, P = 0.002), cg03860400 (BTBD10, P = 0.017) and cg26112390 (GOLGA2P5, P = 0.019) were identified and validated to be the significant CpGs contributed to different HLA-C*0602 groups. Among the hypo- and hypermethylated sites, the top CpGs were in gene body and CpG island.

Conclusion

We performed the first whole-genome study on methylation differences between psoriatic individuals with or without HLA-Cw*0602, and found the key methylation sites which may contribute to the carrying status of HLA-Cw*0602. Methylation loci located in gene body and CpG island are more likely to affect the methylation levels in HLA-Cw*0602 carriers. This integrated analysis shed light on novel insights into the pathogenic mechanisms of genomic methylation in different HLA genotypes of psoriasis."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.org/dc/terms/identifier"doi:10.1016/j.jdermsci.2020.05.006"xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Chen G."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Fang M."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Li M."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Ma H."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Qian Y."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Tang L."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Wang D."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Zhou F."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Zheng X."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/author"Yao T."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/name"J Dermatol Sci"xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/pages"23-29"xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/title"Genomic DNA methylation in HLA-Cw*0602 carriers and non-carriers of psoriasis."xsd:string
http://purl.uniprot.org/citations/32522384http://purl.uniprot.org/core/volume"99"xsd:string
http://purl.uniprot.org/citations/32522384http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32522384
http://purl.uniprot.org/citations/32522384http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32522384
http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-32522384http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32522384
http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-32522384http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32522384
http://purl.uniprot.org/uniprot/#_A0A089N0V0-mappedCitation-32522384http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32522384
▶