| http://purl.uniprot.org/citations/32522994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32522994 | http://www.w3.org/2000/01/rdf-schema#comment | "Translation initiation in human mitochondria relies upon specialized mitoribosomes and initiation factors, mtIF2 and mtIF3, which have diverged from their bacterial counterparts. Here we report two distinct mitochondrial pre-initiation assembly steps involving those factors. Single-particle cryo-EM revealed that in the first step, interactions between mitochondria-specific protein mS37 and mtIF3 keep the small mitoribosomal subunit in a conformation favorable for a subsequent accommodation of mtIF2 in the second step. Combination with fluorescence cross-correlation spectroscopy analyses suggests that mtIF3 promotes complex assembly without mRNA or initiator tRNA binding, where exclusion is achieved by the N-terminal and C-terminal domains of mtIF3. Finally, the association of large mitoribosomal subunit is required for initiator tRNA and leaderless mRNA recruitment to form a stable initiation complex. These data reveal fundamental aspects of mammalian protein synthesis that are specific to mitochondria."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-16503-2"xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/author | "Itoh Y."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/author | "Amunts A."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/author | "Rorbach J."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/author | "Spahr H."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/author | "Khawaja A."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/author | "Remes C."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/author | "Hofig H."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/author | "Yukhnovets O."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/pages | "2932"xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/title | "Distinct pre-initiation steps in human mitochondrial translation."xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32522994 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32522994 |
| http://purl.uniprot.org/citations/32522994 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32522994 |
| http://purl.uniprot.org/uniprot/#_O15235-mappedCitation-32522994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32522994 |
| http://purl.uniprot.org/uniprot/#_Q92552-mappedCitation-32522994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32522994 |
| http://purl.uniprot.org/uniprot/#_Q9Y399-mappedCitation-32522994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32522994 |
| http://purl.uniprot.org/uniprot/#_Q9Y3D3-mappedCitation-32522994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32522994 |
| http://purl.uniprot.org/uniprot/#_Q9Y3D5-mappedCitation-32522994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32522994 |
| http://purl.uniprot.org/uniprot/#_Q9Y3D9-mappedCitation-32522994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32522994 |
| http://purl.uniprot.org/uniprot/#_P51398-mappedCitation-32522994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32522994 |