| http://purl.uniprot.org/citations/32526260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32526260 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer secretion can change the properties of adjacent cells, including peripheral blood mononuclear cells (PBMCs). We investigated whether such secretion influences messenger RNA expression in PBMCs of patients with head and neck squamous cell carcinoma (HNSCC). In the present study, co-culture model of normal PBMCs and HNSCC cell lines were established. The PBMCs were subsequently subjected to RNA sequencing for transcriptome analysis. Furthermore, expression data from the Gene Expression Omnibus repository, platform GPL4133, series GSE39400, were gathered to analyze, afterward identify zinc finger CysCysHisCys (CCHC)-type domain-containing protein 6 (ZCCHC6) as the main gene involved in HNSCC. This gene was then validated by a quantitative real-time polymerase chain reaction. The results showed that ZCCHC6 was expressed at significantly higher levels in the patients with HNSCC than in the healthy controls, and the sensitivity and specificity of these findings for diagnostic purposes were 100.00% and 70.83%, respectively. In summary, our findings demonstrated that the secretion of HNSCC cells could cause the alterations in messenger RNA expression by PBMCs. The ZCCHC6 expression level may apply in HNSCC screening."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2020.144880"xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/author | "Mutirangura A."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/author | "Srisuttee R."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/author | "Kitkumthorn N."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/author | "Arayataweegool A."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/author | "Kerekhanjanarong V."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/author | "Mahattanasakul P."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/author | "Tangjaturonrasme N."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/author | "Bin-Alee F."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/pages | "144880"xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/title | "Induction of ZCCHC6 expression in peripheral blood mononuclear cells by HNSCC secretions."xsd:string |
| http://purl.uniprot.org/citations/32526260 | http://purl.uniprot.org/core/volume | "754"xsd:string |
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