| http://purl.uniprot.org/citations/32535037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32535037 | http://www.w3.org/2000/01/rdf-schema#comment | "Prolonged cardiac hypertrophy, a pathological compensatory response of the heart, finally leads to heart failure. Numerous studies have illustrated the vital roles of non-coding RNAs (ncRNAs) in cardiac hypertrophy. Here, we probed into the role and probable mechanism of microRNA-30e-5p (miR-30e-5p) in Angiotensin II (Ang-II)-stimulated hypertrophic cardiomyocytes. Intriguingly, the expression of hypertrophic markers, cell surface area and protein/DNA ratio were all reduced in Ang-II-induced hypertrophic cardiomyocytes when miR-30e-5p expression was augmented. Then, ADAM9 was screened out as the target of miR-30e-5p and ADAM9 overexpression rescued the effect of miR-30e-5p upregulation in Ang-II-treated cardiomyocytes. Moreover, we identified Kcnq1ot1 as the upstream of miR-30e-5p/ADAM9 axis and verified that Kcnq1ot1 aggrandized ADAM9 expression in Ang-II-treated cardiomyocytes through absorbing miR-30e-5p. Furthermore, rescue assays confirmed that ADAM9 up-regulation abrogated the repressive effect of Kcnq1ot1 depletion on Ang-II-induced cardiac hypertrophy. In conclusion, Kcnq1ot1 sequestered miR-30e-5p to release ADAM9 to facilitate cardiac hypertrophy, indicating that Kcnq1ot1 might be used as a potentially therapeutic target for cardiac hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2020.112140"xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/author | "Ren L."xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/author | "Bao Y."xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/pages | "112140"xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/title | "MiR-30e-5p is sponged by Kcnq1ot1 and represses Angiotensin II-induced hypertrophic phenotypes in cardiomyocytes by targeting ADAM9."xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://purl.uniprot.org/core/volume | "394"xsd:string |
| http://purl.uniprot.org/citations/32535037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32535037 |
| http://purl.uniprot.org/citations/32535037 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32535037 |
| http://purl.uniprot.org/uniprot/#_A0A140LHU0-mappedCitation-32535037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32535037 |
| http://purl.uniprot.org/uniprot/#_Q3UG15-mappedCitation-32535037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32535037 |
| http://purl.uniprot.org/uniprot/#_Q61072-mappedCitation-32535037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32535037 |
| http://purl.uniprot.org/uniprot/#_Q3U1W3-mappedCitation-32535037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32535037 |
| http://purl.uniprot.org/uniprot/Q61072 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32535037 |
| http://purl.uniprot.org/uniprot/Q3U1W3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32535037 |
| http://purl.uniprot.org/uniprot/Q3UG15 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32535037 |
| http://purl.uniprot.org/uniprot/A0A140LHU0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32535037 |