| http://purl.uniprot.org/citations/32535988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32535988 | http://www.w3.org/2000/01/rdf-schema#comment | "CENP-50/U is a component of the CENP-O complex (CENP-O/P/Q/R/U) and localizes to the centromere throughout the cell cycle. Aberrant expression of CENP-50/U has been reported in many types of cancers. However, as Cenp-50/U-deficient mice die during early embryogenesis, its functions remain poorly understood in vivo. To investigate the role of Cenp-50/U in skin carcinogenesis, we generated Cenp-50/U conditional knockout (K14CreER -Cenp-50/Ufl/fl ) mice and subjected them to the 7,12-dimethylbenz(a)anthracene (DMBA)/terephthalic acid (TPA) chemical carcinogenesis protocol. As a result, early-stage papillomas decreased in Cenp-50/U-deficient mice. In contrast, Cenp-50/U-deficient mice demonstrated almost the same carcinoma incidence as control mice. Furthermore, mRNA expression analysis using DMBA/TPA-induced papillomas and carcinomas revealed that Cenp-50/U expression levels in papillomas were significantly higher than in carcinomas. These results suggest that Cenp-50/U functions mainly in early papilloma development and it has little effect on malignant conversion."xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.org/dc/terms/identifier | "doi:10.1111/cas.14533"xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/author | "Kagawa N."xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/author | "Okumura K."xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/author | "Saito M."xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/author | "Isogai E."xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/author | "Wakabayashi Y."xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/author | "Fukagawa T."xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/author | "Munakata H."xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/pages | "2850-2860"xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/title | "CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model."xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/32535988 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32535988 |
| http://purl.uniprot.org/citations/32535988 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32535988 |
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| http://purl.uniprot.org/uniprot/#_A0A1B0GS54-mappedCitation-32535988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32535988 |
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