| http://purl.uniprot.org/citations/32541003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32541003 | http://www.w3.org/2000/01/rdf-schema#comment | "The growth and evolutionary expansion of the cerebral cortex are defined by the spatial-temporal production of neurons, which itself depends on the decision of radial glial cells (RGCs) to self-amplify or to switch to neurogenic divisions. The mechanisms regulating these RGC fate decisions are still incompletely understood. Here, we describe a novel and evolutionarily conserved role of the canonical BMP transcription factors SMAD1/5 in controlling neurogenesis and growth during corticogenesis. Reducing the expression of both SMAD1 and SMAD5 in neural progenitors at early mouse cortical development caused microcephaly and an increased production of early-born cortical neurons at the expense of late-born ones, which correlated with the premature differentiation and depletion of the pool of cortical progenitors. Gain- and loss-of-function experiments performed during early cortical neurogenesis in the chick revealed that SMAD1/5 activity supports self-amplifying RGC divisions and restrains the neurogenic ones. Furthermore, we demonstrate that SMAD1/5 stimulate RGC self-amplification through the positive post-transcriptional regulation of the Hippo signalling effector YAP. We anticipate this SMAD1/5-YAP signalling module to be fundamental in controlling growth and evolution of the amniote cerebral cortex."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.187005"xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/author | "Marti E."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/author | "Martinez J.D."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/author | "Zwijsen A."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/author | "Najas S."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/author | "Arbones M.L."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/author | "Usieto S."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/author | "Esteve-Codina A."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/author | "Le Dreau G."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/author | "Pijuan I."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/pages | "dev187005"xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/title | "A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex."xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/32541003 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32541003 |
| http://purl.uniprot.org/citations/32541003 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32541003 |
| http://purl.uniprot.org/uniprot/#_A0A087WSM9-mappedCitation-32541003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32541003 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUZ7-mappedCitation-32541003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32541003 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP07-mappedCitation-32541003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32541003 |
| http://purl.uniprot.org/uniprot/#_E9Q9N7-mappedCitation-32541003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32541003 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E1-mappedCitation-32541003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32541003 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS00-mappedCitation-32541003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32541003 |