| http://purl.uniprot.org/citations/32543652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32543652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32543652 | http://www.w3.org/2000/01/rdf-schema#comment | "Rcd4 is a poorly characterized Drosophila centriole component whose mammalian counterpart, PPP1R35, is suggested to function in centriole elongation and conversion to centrosomes. Here, we show that rcd4 mutants exhibit fewer centrioles, aberrant mitoses, and reduced basal bodies in sensory organs. Rcd4 interacts with the C-terminal part of Ana3, which loads onto the procentriole during interphase, ahead of Rcd4 and before mitosis. Accordingly, depletion of Ana3 prevents Rcd4 recruitment but not vice versa. We find that neither Ana3 nor Rcd4 participates directly in the mitotic conversion of centrioles to centrosomes, but both are required to load Ana1, which is essential for such conversion. Whereas ana3 mutants are male sterile, reflecting a requirement for Ana3 for centriole development in the male germ line, rcd4 mutants are fertile and have male germ line centrioles of normal length. Thus, Rcd4 is essential in somatic cells but is not absolutely required in spermatogenesis, indicating tissue-specific roles in centriole and basal body formation."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201912154"xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201912154"xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Glover D.M."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Glover D.M."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Kovacs L."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Kovacs L."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Geymonat M."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Geymonat M."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Callaini G."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Callaini G."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Riparbelli M.G."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Riparbelli M.G."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Fatalska A."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Fatalska A."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Dzhindzhev N."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Dzhindzhev N."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Panda P."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Panda P."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Persico V."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/author | "Persico V."xsd:string |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32543652 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |