| http://purl.uniprot.org/citations/32544093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32544093 | http://www.w3.org/2000/01/rdf-schema#comment | "Alcohol-associated liver disease is a spectrum of liver disorders with histopathological changes ranging from simple steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Recent data suggest that chronic-plus-binge ethanol intake induces steatohepatitis by promoting release by hepatocytes of proinflammatory mitochondrial DNA-enriched (mtDNA-enriched) extracellular vesicles (EVs). The aim of the present study was to investigate the role of the stress kinase apoptosis signal-regulating kinase 1 (ASK1) and p38 mitogen-activated protein kinase (p38) in chronic-plus-binge ethanol-induced steatohepatitis and mtDNA-enriched EV release. Microarray analysis revealed the greatest hepatic upregulation of metallothionein 1 and 2 (Mt1/2), which encode 2 of the most potent antioxidant proteins. Genetic deletion of the Mt1 and Mt2 genes aggravated ethanol-induced liver injury, as evidenced by elevation of serum ALT, neutrophil infiltration, oxidative stress, and ASK1/p38 activation in the liver. Inhibition or genetic deletion of Ask1 or p38 ameliorated ethanol-induced liver injury, inflammation, ROS levels, and expression of phagocytic oxidase and ER stress markers in the liver. In addition, inhibition of ASK1 or p38 also attenuated ethanol-induced mtDNA-enriched EV secretion from hepatocytes. Taken together, these findings indicate that induction of hepatic mtDNA-enriched EVs by ethanol is dependent on ASK1 and p38, thereby promoting alcoholic steatohepatitis."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.136496"xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Cao H."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Feng D."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Gao B."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Ren R."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Ren T."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Hwang S."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Liangpunsakul S."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/author | "Rodrigues R.M."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/pages | "136496"xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/title | "Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKalpha-dependent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/32544093 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32544093 |
| http://purl.uniprot.org/citations/32544093 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32544093 |
| http://purl.uniprot.org/uniprot/#_A0A1L1ST18-mappedCitation-32544093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32544093 |
| http://purl.uniprot.org/uniprot/#_D3YVC4-mappedCitation-32544093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32544093 |