| http://purl.uniprot.org/citations/32552000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32552000 | http://www.w3.org/2000/01/rdf-schema#comment | "Colorectal cancer (CRC) patients with KRAS mutation are refractory and usually have poor prognosis. We aimed to identify the hub gene associated with KRAS mutant CRCs. Weighted gene coexpression network analysis (WGCNA) was used to calculate the key module and the hub genes in GSE39582. Combined with the protein-protein interaction (PPI) network and survival analysis, the real hub gene was identified and further validated. With the highest module significance value and correlation coefficient, the blue module was selected as the key module, 19 genes were identified as the hub gene candidates. The above genes were significantly downregulated in KRAS mutant CRCs compared with the wild type. Four genes (AAR2, PSMA7, NELFCD, and PIGU) were further screened as the potential hub genes by the PPI network. Low expression of PIGU for KRAS mutant patients had a poor prognosis. Therefore, PIGU was identified as the hub gene. PIGU expression was also downregulated in other two CRC datasets. "MAPK SIGNALING PATHWAY" was enriched in PIGU lowly expressed samples. PIGU was identified and validated to be closely related to KRAS mutation. It could be a potential prognosis biomarker and a novel treatment target for KRAS mutant CRC patients."xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.org/dc/terms/identifier | "doi:10.1089/dna.2020.5574"xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/author | "Zhou Y.J."xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/author | "Wang H.Z."xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/author | "Peng R.Y."xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/author | "Li H.O."xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/name | "DNA Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/pages | "1639-1648"xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/title | "Identification of PIGU as the Hub Gene Associated with KRAS Mutation in Colorectal Cancer by Coexpression Analysis."xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/32552000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32552000 |
| http://purl.uniprot.org/citations/32552000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32552000 |
| http://purl.uniprot.org/uniprot/#_B4DXB6-mappedCitation-32552000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32552000 |
| http://purl.uniprot.org/uniprot/#_Q9H490-mappedCitation-32552000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32552000 |
| http://purl.uniprot.org/uniprot/Q9H490 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32552000 |
| http://purl.uniprot.org/uniprot/B4DXB6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32552000 |