| http://purl.uniprot.org/citations/32555336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32555336 | http://www.w3.org/2000/01/rdf-schema#comment | "Few studies have investigated the role of extracellular-matrix proteoglycans in the pathogenesis of drug-induced gingival overgrowth (DIGO). SPOCK1 is an extracellular proteoglycan that induces epithelial to mesenchymal transition (EMT) in several cancer cell lines and exhibits protease-inhibitory activity. However, the role of SPOCK1 in non-cancerous diseases such as DIGO has not been well-addressed. We demonstrated that the expression of SPOCK1, TGF-β1, and MMP-9 in calcium channel blocker-induced gingival overgrowth is higher than that in non-overgrowth tissues. Transgenic mice overexpressing Spock1 developed obvious gingival-overgrowth and fibrosis phenotypes, and positively correlated with EMT-like changes. Furthermore, in vitro data indicated a tri-directional interaction between SPOCK1, TGF-β1, and MMP-9 that led to gingival overgrowth. Our study shows that SPOCK1 up-regulation in a noncancerous disease and SPOCK1-induced EMT in gingival overgrowth occurs via cooperation and crosstalk between several potential signaling pathways. Therefore, SPOCK1 is a novel therapeutic target for gingival overgrowth and its expression is a potential risk of EMT induction in cancerous lesions."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-66660-z"xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Fukuda T."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Yamashita A."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Takano A."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Sano T."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Kishida S."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Iwashita M."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Sanada T."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Sanui T."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Nishimura F."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Shinjo T."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/author | "Alshargabi R."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/pages | "9785"xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/title | "SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth."xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/32555336 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32555336 |
| http://purl.uniprot.org/citations/32555336 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32555336 |
| http://purl.uniprot.org/uniprot/#_A0A087WPP6-mappedCitation-32555336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32555336 |
| http://purl.uniprot.org/uniprot/#_B2RXY1-mappedCitation-32555336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32555336 |
| http://purl.uniprot.org/uniprot/#_A0A286YCI6-mappedCitation-32555336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32555336 |
| http://purl.uniprot.org/uniprot/#_Q62288-mappedCitation-32555336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32555336 |