| http://purl.uniprot.org/citations/32555348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32555348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32555348 | http://www.w3.org/2000/01/rdf-schema#comment | "Orderly chromosome segregation is enabled by crossovers between homologous chromosomes in the first meiotic division. Crossovers arise from recombination-mediated repair of programmed DNA double-strand breaks (DSBs). Multiple DSBs initiate recombination, and most are repaired without crossover formation, although one or more generate crossovers on each chromosome. Although the underlying mechanisms are ill-defined, the differentiation and maturation of crossover-specific recombination intermediates requires the cyclin-like CNTD1. Here, we identify PRR19 as a partner of CNTD1. We find that, like CNTD1, PRR19 is required for timely DSB repair and the formation of crossover-specific recombination complexes. PRR19 and CNTD1 co-localise at crossover sites, physically interact, and are interdependent for accumulation, indicating a PRR19-CNTD1 partnership in crossing over. Further, we show that CNTD1 interacts with a cyclin-dependent kinase, CDK2, which also accumulates in crossover-specific recombination complexes. Thus, the PRR19-CNTD1 complex may enable crossover differentiation by regulating CDK2."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-16885-3"xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-16885-3"xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Toth A."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Toth A."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Hunter N."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Hunter N."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Schleiffer A."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Schleiffer A."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Bondarieva A."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Bondarieva A."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Dereli I."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Dereli I."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Fei J.F."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Fei J.F."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Papanikos F."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Papanikos F."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Ravindranathan R."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Ravindranathan R."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Rao H.B.D.P."xsd:string |
| http://purl.uniprot.org/citations/32555348 | http://purl.uniprot.org/core/author | "Rao H.B.D.P."xsd:string |