| http://purl.uniprot.org/citations/32559195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32559195 | http://www.w3.org/2000/01/rdf-schema#comment | "Inactivation of the Rb tumor suppressor causes context-dependent increases in cell proliferation or cell death. In a genetic screen for factors that promoted Rb mutant cell death in Drosophila, we identified Psid, a regulatory subunit of N-terminal acetyltransferase B (NatB). We showed that NatB subunits were required for elevated EGFR/MAPK signaling and Rb mutant cell survival. We showed that NatB regulates the posttranscriptional levels of the highly conserved pathway components Grb2/Drk, MAPK, and PP2AC but not that of the less conserved Sprouty. Interestingly, NatB increased the levels of positive pathway components Grb2/Drk and MAPK while decreased the levels of negative pathway component PP2AC, which were mediated by the distinct N-end rule branch E3 ubiquitin ligases Ubr4 and Cnot4, respectively. These results suggest a novel mechanism by which NatB and N-end rule pathways modulate EGFR/MAPK signaling by inversely regulating the levels of multiple conserved positive and negative pathway components. As inactivation of Psid blocked EGFR signaling-dependent tumor growth, this study raises the possibility that NatB is potentially a novel therapeutic target for cancers dependent on deregulated EGFR/Ras signaling."xsd:string |
| http://purl.uniprot.org/citations/32559195 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1008863"xsd:string |
| http://purl.uniprot.org/citations/32559195 | http://purl.uniprot.org/core/author | "Du W."xsd:string |
| http://purl.uniprot.org/citations/32559195 | http://purl.uniprot.org/core/author | "Sheng Z."xsd:string |
| http://purl.uniprot.org/citations/32559195 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32559195 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/32559195 | http://purl.uniprot.org/core/pages | "e1008863"xsd:string |
| http://purl.uniprot.org/citations/32559195 | http://purl.uniprot.org/core/title | "NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways."xsd:string |
| http://purl.uniprot.org/citations/32559195 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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