| http://purl.uniprot.org/citations/32560811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32560811 | http://www.w3.org/2000/01/rdf-schema#comment | "UCH-L1 is a de-ubiquitination enzyme comprehensively distributed in neural cells and podocytes, which is involved in several kinds of nervous system and kidney related diseases. Our previous studies have demonstrated the aberrant up-regulation of UCH-L1 in podocytes of renal diseases, but how dose podocytes are injured by up-regulated UCH-L1 is waiting to be elucidated. Here, we observed the cytoskeleton rearrangement in podocytes with over-expression of UCH-L1, accompanied with a down-regulation of synaptopodin and RhoA, which are closely related to cytoskeletal stabilization. However, we did not see any alteration of RhoA ubiquitination level under the stimulation of UCH-L1 in podocytes. Subsequently, mass spectrum was applied in UCH-L1-flag immunoprecipitation and plakoglobin was screened out, which was among the UCH-L1-combined proteins and most likely related to cytoskeleton rearrangement. Our experiment demonstrates UCH-L1 may not injure podocytes cytoskeleton through a direct regulation on RhoA/Synaptopodin, but through the regulation of plakoglobin, which could be a promising target for treatment of renal disease in the future."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2020.05.093"xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/author | "Fang Y."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/author | "Mao X."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/author | "Qi C."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/pages | "112-118"xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/title | "Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1."xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://purl.uniprot.org/core/volume | "529"xsd:string |
| http://purl.uniprot.org/citations/32560811 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32560811 |
| http://purl.uniprot.org/citations/32560811 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32560811 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z487-mappedCitation-32560811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32560811 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z495-mappedCitation-32560811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32560811 |
| http://purl.uniprot.org/uniprot/#_B2RD14-mappedCitation-32560811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32560811 |
| http://purl.uniprot.org/uniprot/#_A6NLJ7-mappedCitation-32560811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32560811 |
| http://purl.uniprot.org/uniprot/#_P09936-mappedCitation-32560811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32560811 |
| http://purl.uniprot.org/uniprot/#_P14923-mappedCitation-32560811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32560811 |
| http://purl.uniprot.org/uniprot/#_L8EAA6-mappedCitation-32560811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32560811 |