| http://purl.uniprot.org/citations/32568029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32568029 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteasomal activator 28 gamma (PA28γ), an essential constituent of the 20S proteasome responsible for ubiquitin-independent degradation of target proteins, is frequently overexpressed in hepatocellular carcinoma. Recently, we have reported that hepatitis B virus (HBV) X protein (HBx) activates PA28γ expression in human hepatocytes via upregulation of p53 levels; however, its role in HBV tumorigenesis remains unknown. Here, we found that HBx-activated PA28γ downregulates p16 levels via ubiquitin-independent proteasomal degradation. As a result, HBx activated the Rb-E2F pathway and stimulated G1/S cell cycle progression, resulting in an increase in cell proliferation. The potential of HBx to induce these effects was reproduced in a 1.2-mer HBV replicon and in in vitro HBV infection systems and was almost completely abolished by either PA28γ knockdown or p16 overexpression, demonstrating the critical role of the PA28γ-mediated p16 degradation in HBV tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/32568029 | http://purl.org/dc/terms/identifier | "doi:10.1099/jgv.0.001461"xsd:string |
| http://purl.uniprot.org/citations/32568029 | http://purl.uniprot.org/core/author | "Cha S."xsd:string |
| http://purl.uniprot.org/citations/32568029 | http://purl.uniprot.org/core/author | "Jang K.L."xsd:string |
| http://purl.uniprot.org/citations/32568029 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32568029 | http://purl.uniprot.org/core/name | "J Gen Virol"xsd:string |
| http://purl.uniprot.org/citations/32568029 | http://purl.uniprot.org/core/pages | "963-971"xsd:string |
| http://purl.uniprot.org/citations/32568029 | http://purl.uniprot.org/core/title | "Hepatitis B virus X protein stimulates cell growth by downregulating p16 levels via PA28gamma-mediated proteasomal degradation."xsd:string |
| http://purl.uniprot.org/citations/32568029 | http://purl.uniprot.org/core/volume | "101"xsd:string |
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