| http://purl.uniprot.org/citations/32572027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32572027 | http://www.w3.org/2000/01/rdf-schema#comment | "Interacting with proteins is a crucial way for long noncoding RNAs (lncRNAs) to exert their biological responses. Here we report a high throughput strategy to characterize lncRNA interacting proteins in vivo by combining tobramycin affinity purification and mass spectrometric analysis (TOBAP-MS). Using this method, we identify 140 candidate binding proteins for lncRNA highly upregulated in liver cancer (HULC). Intriguingly, HULC directly binds to two glycolytic enzymes, lactate dehydrogenase A (LDHA) and pyruvate kinase M2 (PKM2). Mechanistic study suggests that HULC functions as an adaptor molecule that enhances the binding of LDHA and PKM2 to fibroblast growth factor receptor type 1 (FGFR1), leading to elevated phosphorylation of these two enzymes and consequently promoting glycolysis. This study provides a convenient method to study lncRNA interactome in vivo and reveals a unique mechanism by which HULC promotes Warburg effect by orchestrating the enzymatic activities of glycolytic enzymes."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-16966-3"xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Zhang N."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Qin G."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Yan S."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Shao X."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Xiao M."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/author | "Kong R."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/pages | "3162"xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/title | "Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2."xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32572027 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32572027 |
| http://purl.uniprot.org/citations/32572027 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32572027 |
| http://purl.uniprot.org/uniprot/#_P00338-mappedCitation-32572027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572027 |
| http://purl.uniprot.org/uniprot/#_P14618-mappedCitation-32572027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572027 |
| http://purl.uniprot.org/uniprot/P14618 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32572027 |
| http://purl.uniprot.org/uniprot/P00338 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32572027 |