| http://purl.uniprot.org/citations/32572622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32572622 | http://www.w3.org/2000/01/rdf-schema#comment | "In the present study, we examined morphology and function of hippocampus in the APC1638T/1638T mouse. Expression levels of the APC mRNA and protein were both identical in the hippocampus of the APC+/+ and APC1638T/1638T mice. The dentate gyrus of the APC1638T/1638T hippocampus was thicker, and has more densely-populated granule cells in the APC1638T/1638T mouse hippocampus. Immunoelectron microscopy revealed co-localization of APC with alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate receptor (AMPA-R) and with PSD-95 at post-synapse in the APC+/+ hippocampus, while APC1638T was co-localized with neither AMPA-R nor PSD-95 in the APC1638T/1638T hippocampus. By immunoprecipitation assay, full-length APC expressed in the APC +/+ mouse was co-immunoprecipitated with AMPA-R and PSD-95. In contrast, APC1638T expressed in the APC1638T/1638T mouse was not co-immunoprecipitated with AMPA-R and PSD-95. In the hippocampal CA1 region of the APC1638T/1638T mouse, c-Fos expression after electric foot shock was decreased compared with the APC+/+ mouse. The present study showed some abnormalities on morphology of the hippocampus caused by a truncated APC (APC1638T). Also, our findings suggest that failure in APC binding to AMPA-R and PSD-95 may bring about less activities of hippocampal neurons in the APC1638T/1638T mouse."xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00795-020-00257-3"xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/author | "Matsuda S."xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/author | "Senda T."xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/author | "Sakai K."xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/author | "Hirayama M."xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/author | "Onouchi T."xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/author | "Yamada N.O."xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/name | "Med Mol Morphol"xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/pages | "31-40"xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/title | "Morphological and functional abnormalities of hippocampus in APC1638T/1638T mice."xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/32572622 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32572622 |
| http://purl.uniprot.org/citations/32572622 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32572622 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-32572622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572622 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-32572622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572622 |
| http://purl.uniprot.org/uniprot/#_Q8BRD8-mappedCitation-32572622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572622 |
| http://purl.uniprot.org/uniprot/#_Q3UQT2-mappedCitation-32572622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572622 |
| http://purl.uniprot.org/uniprot/#_Q8BNP7-mappedCitation-32572622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572622 |
| http://purl.uniprot.org/uniprot/#_Q61315-mappedCitation-32572622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572622 |
| http://purl.uniprot.org/uniprot/#_Q8C493-mappedCitation-32572622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572622 |
| http://purl.uniprot.org/uniprot/#_Q8C9I9-mappedCitation-32572622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32572622 |