| http://purl.uniprot.org/citations/32575075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32575075 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptic neurodegeneration of retinal ganglion cells (RGCs) is the earliest event in the pathogenesis of diabetic retinopathy. Our previous study proposed that impairment of mitochondrial trafficking by hyperphosphorylated tau is a potential contributor to RGCs synapse degeneration. However, other molecular mechanisms underlying mitochondrial defect in diabetic retinal neurodegeneration remain to be elucidated. Here, using a high-fat diet (HFD)-induced diabetic mouse model, we showed for the first time that downregulation of active β-catenin due to abnormal GSK3β activation caused synaptic neurodegeneration of RGCs by inhibiting ROS scavenging enzymes, thus triggering oxidative stress-driven mitochondrial impairment in HFD-induced diabetes. Rescue of β-catenin via ectopic expression of β-catenin with a recombinant adenoviral vector, or via GSK3β inhibition by a targeted si-GSK3β, through intravitreal administration, abrogated the oxidative stress-derived mitochondrial defect and synaptic neurodegeneration in diabetic RGCs. By contrast, ablation of β-catenin by si-β-catenin abolished the protective effect of GSK3β inhibition on diabetic RGCs by suppression of antioxidant scavengers and augmentation of oxidative stress-driven mitochondrial lesion. Thus, our data identify β-catenin as a part of an endogenous protective system in diabetic RGCs and a promising target to develop intervention strategies that protect RGCs from neurodegeneration at early onset of diabetic retinopathy."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.103446"xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/author | "Zhu H."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/author | "Ying Y."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/author | "Shu X.S."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/pages | "13437-13462"xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/title | "Loss of beta-catenin via activated GSK3beta causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment."xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/32575075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32575075 |
| http://purl.uniprot.org/citations/32575075 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32575075 |
| http://purl.uniprot.org/uniprot/#_B4DGU4-mappedCitation-32575075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575075 |
| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-32575075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575075 |
| http://purl.uniprot.org/uniprot/#_B2ZRE2-mappedCitation-32575075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575075 |
| http://purl.uniprot.org/uniprot/#_B2ZRG2-mappedCitation-32575075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575075 |
| http://purl.uniprot.org/uniprot/#_B4DL06-mappedCitation-32575075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575075 |
| http://purl.uniprot.org/uniprot/#_B5BU28-mappedCitation-32575075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575075 |
| http://purl.uniprot.org/uniprot/#_G9GAG7-mappedCitation-32575075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575075 |