| http://purl.uniprot.org/citations/32575457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32575457 | http://www.w3.org/2000/01/rdf-schema#comment | "ATP-binding cassette transporter A1 (ABCA1) plays an important role in the regulation of apolipoprotein E (ApoE) and the biogenesis of high-density lipoprotein (HDL) cholesterol in the mammalian brain. Cholesterol is a major source for myelination. Here, we investigate whether ABCA1/ApoE/HDL contribute to myelin repair and oligodendrogenesis in the ischemic brain after stroke. Specific brain ABCA1-deficient (ABCA1-B/-B) and ABCA1-floxed (ABCA1fl/fl) control mice were subjected to permanent distal middle-cerebral-artery occlusion (dMCAo) and were intracerebrally administered (1) artificial mouse cerebrospinal fluid (CSF) as vehicle control, (2) human plasma HDL3, and (3) recombined human ApoE2 starting 24 h after dMCAo for 14 days. All stroke mice were sacrificed 21 days after dMCAo. The ABCA1-B/-B-dMCAo mice exhibit significantly reduced myelination and oligodendrogenesis in the ischemic brain as well as decreased functional outcome 21 days after stroke compared with ABCA1fl/fl mice; administration of human ApoE2 or HDL3 in the ischemic brain significantly attenuates the deficits in myelination and oligodendrogenesis in ABCA1-B/-B-dMCAo mice ( p < 0.05, n = 9/group). In vitro, ABCA1-B/-B reduces ApoE expression and decreases primary oligodendrocyte progenitor cell (OPC) migration and oligodendrocyte maturation; HDL3 and ApoE2 treatment significantly reverses ABCA1-B/-B-induced reduction in OPC migration and oligodendrocyte maturation. Our data indicate that the ABCA1/ApoE/HDL signaling pathway contributes to myelination and oligodendrogenesis in the ischemic brain after stroke."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms21124369"xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/author | "Cui X."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/author | "Zacharek A."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/author | "Chopp M."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/author | "Landschoot-Ward J."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/pages | "E4369"xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/title | "ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke."xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/32575457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32575457 |
| http://purl.uniprot.org/citations/32575457 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32575457 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3B1-mappedCitation-32575457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575457 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3V0-mappedCitation-32575457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575457 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D5-mappedCitation-32575457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575457 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3J5-mappedCitation-32575457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575457 |
| http://purl.uniprot.org/uniprot/#_A0A346DBY2-mappedCitation-32575457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575457 |
| http://purl.uniprot.org/uniprot/#_D9ZB55-mappedCitation-32575457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575457 |
| http://purl.uniprot.org/uniprot/#_P41233-mappedCitation-32575457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32575457 |