| http://purl.uniprot.org/citations/32578350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32578350 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasma cells (PCs), which aim to protect host health, produce various subsets of immunoglobulin (Ig) in response to extracellular pathogens. Blimp-1 (encoded by Prdm1)-a protein that is highly expressed by PCs-is important for PC functions, including the generation of Igs. Fatty acid-binding protein 3 (FABP3) is a carrier protein of polyunsaturated fatty acids (PUFAs) and participates in multiple cellular functions. Although the functions of FABP3 in neurons and cardiac myocytes are well-noted, their roles in immune cells remain to be fully elucidated. In this study, we demonstrate that FABP3 is expressed in activated B cells and that FABP3 promotes PC development and IgM secretion. Moreover, we provide the first evidence that FABP3 is necessary for Blimp-1 expression, by regulating the histone modification of its promoter region. Taken together, our findings reveal that FABP3 acts as a positive regulator of B-cell activation by controlling histone acetylation of the Blimp-1 gene, thereby playing a role in host defense against pathogens."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.org/dc/terms/identifier | "doi:10.1111/febs.15460"xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/author | "Ishii N."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/author | "Maruyama T."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/author | "Yamamoto Y."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/author | "Kagawa Y."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/author | "Owada Y."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/author | "Miyazaki H."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/author | "Tayama S."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/author | "Phung H.T."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/name | "FEBS J"xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/pages | "1130-1141"xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/title | "Fatty acid-binding protein 3 regulates differentiation of IgM-producing plasma cells."xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/32578350 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32578350 |
| http://purl.uniprot.org/citations/32578350 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32578350 |
| http://purl.uniprot.org/uniprot/#_P11404-mappedCitation-32578350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32578350 |
| http://purl.uniprot.org/uniprot/#_Q5EBJ0-mappedCitation-32578350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32578350 |
| http://purl.uniprot.org/uniprot/P11404 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32578350 |
| http://purl.uniprot.org/uniprot/Q5EBJ0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32578350 |