| http://purl.uniprot.org/citations/32579115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32579115 | http://www.w3.org/2000/01/rdf-schema#comment | "To date, microglia subsets in the healthy CNS have not been identified. Utilizing autofluorescence (AF) as a discriminating parameter, we identified two novel microglia subsets in both mice and non-human primates, termed autofluorescence-positive (AF+) and negative (AF-). While their proportion remained constant throughout most adult life, the AF signal linearly and specifically increased in AF+ microglia with age and correlated with a commensurate increase in size and complexity of lysosomal storage bodies, as detected by transmission electron microscopy and LAMP1 levels. Post-depletion repopulation kinetics revealed AF- cells as likely precursors of AF+ microglia. At the molecular level, the proteome of AF+ microglia showed overrepresentation of endolysosomal, autophagic, catabolic, and mTOR-related proteins. Mimicking the effect of advanced aging, genetic disruption of lysosomal function accelerated the accumulation of storage bodies in AF+ cells and led to impaired microglia physiology and cell death, suggestive of a mechanistic convergence between aging and lysosomal storage disorders."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.57495"xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Wei R."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Ransohoff R.M."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Walther D.M."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Burns J.C."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Cotman S.L."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Rubino S.J."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Franchimont N."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Mingueneau M."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Bajrami B."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/author | "Cotleur B."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/pages | "e57495"xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/title | "Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain."xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32579115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32579115 |
| http://purl.uniprot.org/citations/32579115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32579115 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVS1-mappedCitation-32579115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32579115 |
| http://purl.uniprot.org/uniprot/#_D3YVA8-mappedCitation-32579115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32579115 |
| http://purl.uniprot.org/uniprot/#_A0A385JBX3-mappedCitation-32579115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32579115 |
| http://purl.uniprot.org/uniprot/#_A0A498WGS3-mappedCitation-32579115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32579115 |
| http://purl.uniprot.org/uniprot/#_A0A411P8U6-mappedCitation-32579115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32579115 |