| http://purl.uniprot.org/citations/32579967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32579967 | http://www.w3.org/2000/01/rdf-schema#comment | "How are diverse regulatory strategies integrated to impose appropriately patterned gene expression that underlie in vivo phenotypes? Here, we reveal how coordinated miRNA regulation and neural-specific alternative polyadenylation (APA) of a single locus controls complex behaviors. Our entry was the unexpected observation that deletion of Bithorax complex (BX-C) miRNAs converts virgin female flies into a subjective post-mated behavioral state, normally induced by seminal proteins following copulation. Strikingly, this behavioral switch is directly attributable to misregulation of homothorax (hth). We localize specific CNS abdominal neurons where de-repressed Hth compromises virgin behavior in BX-C miRNA mutants. Moreover, we use genome engineering to demonstrate that precise mutation of hth 3' UTR sites for BX-C miRNAs or deletion of its neural 3' UTR extension containing most of these sites both induce post-mated behaviors in virgins. Thus, facilitation of miRNA-mediated repression by neural APA is required for virgin females to execute behaviors appropriate to their internal state."xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2020.06.004"xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/author | "Wei L."xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/author | "Li E."xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/author | "Lai E.C."xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/author | "Garaulet D.L."xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/pages | "410-423.e4"xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/title | "miRNAs and Neural Alternative Polyadenylation Specify the Virgin Behavioral State."xsd:string |
| http://purl.uniprot.org/citations/32579967 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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