| http://purl.uniprot.org/citations/32580934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32580934 | http://www.w3.org/2000/01/rdf-schema#comment | "Melanoblasts disperse throughout the skin and populate hair follicles through long-range cell migration. During migration, cells undergo cycles of coordinated attachment and detachment from the extracellular matrix (ECM). Embryonic migration processes that require cell-ECM attachment are dependent on the integrin family of adhesion receptors. Precise regulation of integrin-mediated adhesion is important for many developmental migration events. However, the mechanisms that regulate integrin-mediated adhesion in vivo in melanoblasts are not well understood. Here, we show that autoinhibitory regulation of the integrin-associated adapter protein talin coordinates cell-ECM adhesion during melanoblast migration in vivo Specifically, an autoinhibition-defective talin mutant strengthens and stabilizes integrin-based adhesions in melanocytes, which impinges on their ability to migrate. Mice with defective talin autoinhibition exhibit delays in melanoblast migration and pigmentation defects. Our results show that coordinated integrin-mediated cell-ECM attachment is essential for melanoblast migration and that talin autoinhibition is an important mechanism for fine-tuning cell-ECM adhesion during cell migration in development."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.184234"xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Deng W."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Mitchell C."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Wagner K."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Venkatesh B."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Lefebvre L."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Tanentzapf G."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Van Raamsdonk C.D."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Goodwin K."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Bogutz A."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/author | "Haage A."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/pages | "dev184234"xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/title | "Precise coordination of cell-ECM adhesion is essential for efficient melanoblast migration during development."xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/32580934 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32580934 |
| http://purl.uniprot.org/citations/32580934 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32580934 |
| http://purl.uniprot.org/uniprot/#_A0A140LHU8-mappedCitation-32580934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32580934 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRC0-mappedCitation-32580934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32580934 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT69-mappedCitation-32580934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32580934 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPB5-mappedCitation-32580934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32580934 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSI7-mappedCitation-32580934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32580934 |