| http://purl.uniprot.org/citations/32584791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32584791 | http://www.w3.org/2000/01/rdf-schema#comment | "DCs are a critical component of immune responses in cancer primarily due to their ability to cross-present tumor-associated antigens. Cross-presentation by DCs in cancer is impaired, which may represent one of the obstacles for the success of cancer immunotherapies. Here, we report that polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) blocked cross-presentation by DCs without affecting direct presentation of antigens by these cells. This effect did not require direct cell-cell contact and was associated with transfer of lipids. Neutrophils (PMN) and PMN-MDSC transferred lipid to DCs equally well; however, PMN did not affect DC cross-presentation. PMN-MDSC generate oxidatively truncated lipids previously shown to be involved in impaired cross-presentation by DCs. Accumulation of oxidized lipids in PMN-MDSC was dependent on myeloperoxidase (MPO). MPO-deficient PMN-MDSC did not affect cross-presentation by DCs. Cross-presentation of tumor-associated antigens in vivo by DCs was improved in MDSC-depleted or tumor-bearing MPO-KO mice. Pharmacological inhibition of MPO in combination with checkpoint blockade reduced tumor progression in different tumor models. These data suggest MPO-driven lipid peroxidation in PMN-MDSC as a possible non-cell autonomous mechanism of inhibition of antigen cross-presentation by DCs and propose MPO as potential therapeutic target to enhance the efficacy of current immunotherapies for patients with cancer."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci.insight.138581"xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/author | "Kagan V.E."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/author | "Tyurin V.A."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/author | "Tyurina Y.Y."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/author | "Veglia F."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/author | "Ugolini A."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/author | "Gabrilovich D.I."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/author | "Donthireddy L."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/author | "Tcyganov E.N."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/name | "JCI Insight"xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/pages | "138581"xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/title | "Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer."xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/32584791 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32584791 |
| http://purl.uniprot.org/citations/32584791 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32584791 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQL9-mappedCitation-32584791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32584791 |
| http://purl.uniprot.org/uniprot/#_E9Q7S3-mappedCitation-32584791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32584791 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRS5-mappedCitation-32584791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32584791 |
| http://purl.uniprot.org/uniprot/#_E9Q802-mappedCitation-32584791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32584791 |
| http://purl.uniprot.org/uniprot/#_F7DC05-mappedCitation-32584791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32584791 |
| http://purl.uniprot.org/uniprot/#_F8WGZ9-mappedCitation-32584791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32584791 |
| http://purl.uniprot.org/uniprot/#_Q3U2C3-mappedCitation-32584791 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32584791 |