| http://purl.uniprot.org/citations/32585853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32585853 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiogenesis process contributes to the pathogenesis of B-cell chronic lymphocytic leukemia (B-CLL) being the levels of VEGFA and bFGF higher in patients than in healthy controls. Our aim was to evaluate the implication of angiogenesis factors genetic variants in the predisposition to B-CLL and their association with clinical factors and survival. We performed a population-based case-control study in 224 Spanish B-CLL patients and 476 healthy randomly selected controls to evaluate susceptibility to developing B-CLL. Six polymorphisms were evaluated: rs1109324, rs1547651, rs3025039 (+936 C>T), rs833052 of the VEGFA gene, rs1449683 (c.233C>T) of the bFGF gene and (-710 C>T) of the VEGFR1 gene. The association between clinical parameters and patient outcome was analyzed. Carriers of the CT/TT variants of rs3025039 showed a significant protective effect against developing B-CLL. The CT/TT variants of rs1449683 show a tendency towards the development of the disease and the same variants associated significantly with higher genetic risk and with reduced disease free survival. Moreover, the association persisted in the early-stage disease subgroup. Our study provides evidence of the protective effect of the T/-rs3025039 VEGFA variant against B-CLL development and the association of CT/TT variants of the rs1449683 bFGF gene with genetic risk and an adverse survival."xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.org/dc/terms/identifier | "doi:10.3390/genes11060686"xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/author | "Rodrigues P."xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/author | "Eroles P."xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/author | "Ballester S."xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/author | "Pineda B."xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/author | "Terol M.J."xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/author | "Tormo E."xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/name | "Genes (Basel)"xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/pages | "E686"xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/title | "Clinical Relevance of +936 C>T VEGFA and c.233C>T bFGF Polymorphisms in Chronic Lymphocytic Leukemia."xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32585853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32585853 |
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