| http://purl.uniprot.org/citations/32586950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32586950 | http://www.w3.org/2000/01/rdf-schema#comment | "Ribonuclease (RNase) MRP is a conserved eukaryotic ribonucleoprotein complex that plays essential roles in precursor ribosomal RNA (pre-rRNA) processing and cell cycle regulation. In contrast to RNase P, which selectively cleaves transfer RNA-like substrates, it has remained a mystery how RNase MRP recognizes its diverse substrates. To address this question, we determined cryo-electron microscopy structures of Saccharomyces cerevisiae RNase MRP alone and in complex with a fragment of pre-rRNA. These structures and the results of biochemical studies reveal that coevolution of both protein and RNA subunits has transformed RNase MRP into a distinct ribonuclease that processes single-stranded RNAs by recognizing a short, loosely defined consensus sequence. This broad substrate specificity suggests that RNase MRP may have myriad yet unrecognized substrates that could play important roles in various cellular contexts."xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abc0149"xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/author | "Cao M."xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/author | "Lei M."xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/author | "Tan M."xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/author | "Zhou B."xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/author | "Lan P."xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/pages | "656-663"xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/title | "Structural insight into precursor ribosomal RNA processing by ribonuclease MRP."xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://purl.uniprot.org/core/volume | "369"xsd:string |
| http://purl.uniprot.org/citations/32586950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32586950 |
| http://purl.uniprot.org/citations/32586950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32586950 |
| http://purl.uniprot.org/uniprot/P38291#attribution-F7FA3BE25FEC4A28367054F01A64BDFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32586950 |
| http://purl.uniprot.org/uniprot/P28005#attribution-F7FA3BE25FEC4A28367054F01A64BDFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32586950 |
| http://purl.uniprot.org/uniprot/P53833#attribution-F7FA3BE25FEC4A28367054F01A64BDFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32586950 |
| http://purl.uniprot.org/uniprot/P38336#attribution-F7FA3BE25FEC4A28367054F01A64BDFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32586950 |
| http://purl.uniprot.org/uniprot/P38208#attribution-F7FA3BE25FEC4A28367054F01A64BDFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32586950 |
| http://purl.uniprot.org/uniprot/P53218#attribution-F7FA3BE25FEC4A28367054F01A64BDFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32586950 |
| http://purl.uniprot.org/uniprot/P41812#attribution-F7FA3BE25FEC4A28367054F01A64BDFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32586950 |
| http://purl.uniprot.org/uniprot/P40993#attribution-F7FA3BE25FEC4A28367054F01A64BDFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/32586950 |