| http://purl.uniprot.org/citations/32599080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32599080 | http://www.w3.org/2000/01/rdf-schema#comment | "A large body of evidence suggests a relationship between depression and coronary heart disease (CHD). Angiotensin-Ⅱ (Ang-Ⅱ) and angiotensin-(1-7) [Ang-(1-7)] are considered to exert biological effects in both conditions. Here, we aimed to determine the role of Ang-Ⅱ and Ang-(1-7) in the occurrence of comorbid depression in patients with CHD. Our study included 214 CHD patients and 100 matched healthy controls. Serum Ang-Ⅱ and Ang-(1-7) levels were assessed by ELISA, and the depression symptoms were evaluated by the nine-item Patient Health Questionnaire (PHQ-9). Linear regression and correlation analyses were used to estimate the associations between PHQ-9 scores and Ang-Ⅱ and Ang-(1-7) serum levels. Six single-nucleotide polymorphisms (SNPs) spanning the angiotensin converting enzyme 2 (ACE2) and MAS1 genes were genotyped. The associations between SNPs and depression risk in CHD patients were examined using logistic regression analysis with adjustment for age and gender. Decreased Ang-(1-7) (P < 0.05) and an elevated Ang-Ⅱ/Ang-(1-7) ratio (P < 0.01) were observed in CHD patients with depression compared to CHD patients without depression. PHQ-9 scores were negatively correlated with Ang-(1-7) level (r=-0.44, P < 0.01) and positively correlated with the Ang-Ⅱ/Ang-(1-7) ratio (r = 0.33, P < 0.05). Furthermore, carriers of risk allele T for CHD with depression had significantly higher PHQ-9 scores (P < 0.05), lower Ang-(1-7) level (P < 0.01), and higher Ang-Ⅱ/Ang-(1-7) ratio (P < 0.05) than those CC carriers. Collectively, our results firstly showed that Ang-(1-7) serum level in CHD patients may protect against comorbid depression. Moreover, the imbalance between Ang-Ⅱ and Ang-(1-7) may contribute to depression in CHD patients."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2020.170353"xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/author | "Feng Q."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/author | "Han W."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/author | "Jiang P."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/author | "Wei Z."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/author | "Geng C."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/author | "Dang R."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/pages | "170353"xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/title | "Angiotensin-Ⅱ and angiotensin-(1-7) imbalance affects comorbidity of depression and coronary heart disease."xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/32599080 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32599080 |
| http://purl.uniprot.org/citations/32599080 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32599080 |
| http://purl.uniprot.org/uniprot/#_A0A8S0M502-mappedCitation-32599080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32599080 |
| http://purl.uniprot.org/uniprot/#_B2RCJ5-mappedCitation-32599080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32599080 |
| http://purl.uniprot.org/uniprot/#_P04201-mappedCitation-32599080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32599080 |
| http://purl.uniprot.org/uniprot/#_Q9BYF1-mappedCitation-32599080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32599080 |
| http://purl.uniprot.org/uniprot/#_W8W3P4-mappedCitation-32599080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32599080 |
| http://purl.uniprot.org/uniprot/A0A8S0M502 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32599080 |