| http://purl.uniprot.org/citations/32606301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32606301 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial lysine acetylation regulates several metabolic pathways in cardiac cells. The current study investigated whether GCN5L1-mediated lysine acetylation regulates cardiac mitochondrial metabolic proteins in response to a high fat diet (HFD). GCN5L1 cardiac-specific knockout (cKO) mice showed significantly reduced mitochondrial protein acetylation following a HFD relative to wildtype (WT) mice. GCN5L1 cKO mice did not display any decrease in ex vivo cardiac workload in response to a HFD. In contrast, ex vivo cardiac function in HFD-fed WT mice dropped ~ 50% relative to low fat diet (LFD) fed controls. The acetylation status of electron transport chain Complex I protein NDUFB8 was significantly increased in WT mice fed a HFD, but remained unchanged in GCN5L1 cKO mice relative to LFD controls. Finally, we observed that inhibitory acetylation of superoxide dismutase 2 (SOD2) at K122 was increased in WT (but not cKO mice) on a HFD. This correlated with significantly increased cardiac lipid peroxidation in HFD-fed WT mice relative to GCN5L1 cKO animals under the same conditions. We conclude that increased GCN5L1 expression in response to a HFD promotes increased lysine acetylation, and that this may play a role in the development of reactive oxygen species (ROS) damage caused by nutrient excess."xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-67812-x"xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/author | "Xie B."xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/author | "Scott I."xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/author | "Thapa D."xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/author | "Stoner M.W."xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/author | "Manning J.R."xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/pages | "10665"xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/title | "Cardiomyocyte-specific deletion of GCN5L1 in mice restricts mitochondrial protein hyperacetylation in response to a high fat diet."xsd:string |
| http://purl.uniprot.org/citations/32606301 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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