| http://purl.uniprot.org/citations/32610038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32610038 | http://www.w3.org/2000/01/rdf-schema#comment | "Meiotic recombination proceeds via binding of RPA, RAD51, and DMC1 to single-stranded DNA (ssDNA) substrates created after formation of programmed DNA double-strand breaks. Here we report high-resolution in vivo maps of RPA and RAD51 in meiosis, mapping their binding locations and lifespans to individual homologous chromosomes using a genetically engineered hybrid mouse. Together with high-resolution microscopy and DMC1 binding maps, we show that DMC1 and RAD51 have distinct spatial localization on ssDNA: DMC1 binds near the break site, and RAD51 binds away from it. We characterize inter-homolog recombination intermediates bound by RPA in vivo, with properties expected for the critical displacement loop (D-loop) intermediates. These data support the hypothesis that DMC1, not RAD51, performs strand exchange in mammalian meiosis. RPA-bound D-loops can be resolved as crossovers or non-crossovers, but crossover-destined D-loops may have longer lifespans. D-loops resemble crossover gene conversions in size, but their extent is similar in both repair pathways."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2020.06.015"xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Shi Q."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Davies B."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Moralli D."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Donnelly P."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Keeney S."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Green C."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Becker P.W."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Hinch A.G."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/author | "Bycroft C."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/pages | "689-701.e10"xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/title | "The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates."xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/32610038 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32610038 |
| http://purl.uniprot.org/citations/32610038 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32610038 |
| http://purl.uniprot.org/uniprot/#_D2E439-mappedCitation-32610038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610038 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHC3-mappedCitation-32610038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610038 |
| http://purl.uniprot.org/uniprot/#_A3KGI2-mappedCitation-32610038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610038 |
| http://purl.uniprot.org/uniprot/#_D2KI92-mappedCitation-32610038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610038 |