| http://purl.uniprot.org/citations/32610126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32610126 | http://www.w3.org/2000/01/rdf-schema#comment | "Activated macrophages must carefully calibrate their inflammatory responses to balance efficient pathogen control with inflammation-mediated tissue damage, but the molecular underpinnings of this "balancing act" remain unclear. Using genetically engineered mouse models and primary macrophage cultures, we show that Toll-like receptor (TLR) signaling induces the expression of the transcription factor Spic selectively in patrolling monocytes and tissue macrophages by a nuclear factor κB (NF-κB)-dependent mechanism. Functionally, Spic downregulates pro-inflammatory cytokines and promotes iron efflux by regulating ferroportin expression in activated macrophages. Notably, interferon-gamma blocks Spic expression in a STAT1-dependent manner. High levels of interferon-gamma are indicative of ongoing infection, and in its absence, activated macrophages appear to engage a "default" Spic-dependent anti-inflammatory pathway. We also provide evidence for the engagement of this pathway in sterile inflammation. Taken together, our findings uncover a pathway wherein counter-regulation of Spic by NF-κB and STATs attune inflammatory responses and iron metabolism in macrophages."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.107825"xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Bhattacharyya A."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Chen Y.H."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Alam Z."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Young P."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Bhattacharya M."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Haldar M."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Silverman M.A."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Dang M.T."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Levine M.H."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Wilbur C.J."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "To T.K.J."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Devalaraja S."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Folkert I.W."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Hernandez P.T."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/author | "Mitchell-Velasquez E."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/pages | "107825"xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/title | "Counter Regulation of Spic by NF-kappaB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages."xsd:string |
| http://purl.uniprot.org/citations/32610126 | http://purl.uniprot.org/core/volume | "31"xsd:string |