| http://purl.uniprot.org/citations/32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32610146 | http://www.w3.org/2000/01/rdf-schema#comment | "Microtubule organization depends on the γ-tubulin ring complex (γ-TuRC), a ∼2.3-MDa nucleation factor comprising an asymmetric assembly of γ-tubulin and GCP2-GCP6. However, it is currently unclear how the γ-TuRC-associated microproteins MZT1 and MZT2 contribute to the structure and regulation of the holocomplex. Here, we report cryo-EM structures of MZT1 and MZT2 in the context of the native human γ-TuRC. MZT1 forms two subcomplexes with the N-terminal α-helical domains of GCP3 or GCP6 (GCP-NHDs) within the γ-TuRC "lumenal bridge." We determine the X-ray structure of recombinant MZT1/GCP6-NHD and find it is similar to that within the native γ-TuRC. We identify two additional MZT/GCP-NHD-like subcomplexes, one of which is located on the outer face of the γ-TuRC and comprises MZT2 and GCP2-NHD in complex with a centrosomin motif 1 (CM1)-containing peptide. Our data reveal how MZT1 and MZT2 establish multi-faceted, structurally mimetic "modules" that can expand structural and regulatory interfaces in the γ-TuRC."xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.107791"xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/author | "Kapoor T.M."xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/author | "Urnavicius L."xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/author | "Wieczorek M."xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/author | "Hsia K.C."xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/author | "Huang T.L."xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/pages | "107791"xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/title | "MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex."xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/32610146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32610146 |
| http://purl.uniprot.org/citations/32610146 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32610146 |
| http://purl.uniprot.org/uniprot/#_B8ZZ87-mappedCitation-32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610146 |
| http://purl.uniprot.org/uniprot/#_Q53SH9-mappedCitation-32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610146 |
| http://purl.uniprot.org/uniprot/#_Q08AG7-mappedCitation-32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610146 |
| http://purl.uniprot.org/uniprot/#_Q6P582-mappedCitation-32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610146 |
| http://purl.uniprot.org/uniprot/#_Q6NZ67-mappedCitation-32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610146 |
| http://purl.uniprot.org/uniprot/#_Q96CW5-mappedCitation-32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610146 |
| http://purl.uniprot.org/uniprot/#_Q96RT7-mappedCitation-32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610146 |
| http://purl.uniprot.org/uniprot/#_Q96SN8-mappedCitation-32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610146 |
| http://purl.uniprot.org/uniprot/#_Q9BSJ2-mappedCitation-32610146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32610146 |
| http://purl.uniprot.org/uniprot/Q6P582 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32610146 |