| http://purl.uniprot.org/citations/32620768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32620768 | http://www.w3.org/2000/01/rdf-schema#comment | "A sharp increase in mitochondrial Ca2+ marks the activation of brown adipose tissue (BAT) thermogenesis, yet the mechanisms preventing Ca2+ deleterious effects are poorly understood. Here, we show that adrenergic stimulation of BAT activates a PKA-dependent mitochondrial Ca2+ extrusion via the mitochondrial Na+/Ca2+ exchanger, NCLX. Adrenergic stimulation of NCLX-null brown adipocytes (BA) induces a profound mitochondrial Ca2+ overload and impaired uncoupled respiration. Core body temperature, PET imaging of glucose uptake and VO2 measurements confirm a thermogenic defect in NCLX-null mice. We show that Ca2+ overload induced by adrenergic stimulation of NCLX-null BAT, triggers the mitochondrial permeability transition pore (mPTP) opening, leading to a remarkable mitochondrial swelling and cell death. Treatment with mPTP inhibitors rescue mitochondrial function and thermogenesis in NCLX-null BAT, while calcium overload persists. Our findings identify a key pathway through which BA evade apoptosis during adrenergic stimulation of uncoupling. NCLX deletion transforms the adrenergic pathway responsible for thermogenesis activation into a death pathway."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-16572-3"xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Miller N."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Liesa M."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Shirihai O.S."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Sekler I."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Acin-Perez R."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Jones A.E."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Oliveira M.F."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Taha M."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Las G."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Shum M."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Assali E.A."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/author | "Veliova M."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/pages | "3347"xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/title | "NCLX prevents cell death during adrenergic activation of the brown adipose tissue."xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32620768 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32620768 |
| http://purl.uniprot.org/citations/32620768 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32620768 |
| http://purl.uniprot.org/uniprot/#_D3Z226-mappedCitation-32620768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32620768 |
| http://purl.uniprot.org/uniprot/#_D3Z5E7-mappedCitation-32620768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32620768 |
| http://purl.uniprot.org/uniprot/#_Q925Q3-mappedCitation-32620768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32620768 |